{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:21:29Z","timestamp":1790418089157,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the impact of general practice nurse\u2010led interventions for blood pressure control and cardiovascular disease risk factor reduction in patients with hypertension. Systematic review and meta\u2010analysis of randomized control trials. CINAHL, Medline and Scopus databases were searched to identify peer\u2010reviewed studies published between 2000 and 2021. A systematic review of randomized control trials was conducted using a structured search strategy. The Meta\u2010Analysis of Statistics Assessment and Review Instrument (JBI\u2010MAStARI) was used to appraise study quality. Meta\u2010analysis and narrative synthesis were performed to determine the effectiveness of the included interventions. Eleven trials comprising of 4454 participants were included in the review. Meta\u2010analysis showed significant reductions in both systolic and diastolic blood pressure in trials with 6\u00a0months or less follow\u2010up. Improvements were also demonstrated in reducing blood lipids, physical activity, general lifestyle measures and medication adherence. Evidence for dietary improvements and reduction in alcohol and smoking rates was inconclusive. Nurse\u2010led interventions for patients with hypertension are heterogeneous in terms of the nature of the intervention and outcomes measured. However, nurse\u2010led interventions in general practice demonstrate significant potential to improve blood pressure and support cardiovascular disease risk factor reduction. Future research should be directed towards elucidating the successful elements of these interventions, evaluating cost\u2010effectiveness and exploring translation into usual care. This review provides evidence that nurses in general practice could enhance current hypertension management through nurse\u2010led interventions.<\/jats:p>","DOI":"10.1111\/jan.15159","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T09:08:55Z","timestamp":1646384935000},"page":"1281-1293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Nurse\u2010led interventions to manage hypertension in general practice: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-1300","authenticated-orcid":false,"given":"Catherine","family":"Stephen","sequence":"first","affiliation":[{"name":"School of Nursing, Faculty of Science, Medicine &amp; Health University of Wollongong Illawarra Health &amp; Medical Research Institute  Wollongong New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-986X","authenticated-orcid":false,"given":"Elizabeth","family":"Halcomb","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Science, Medicine &amp; 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