{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:21:35Z","timestamp":1787649695095,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020230","name":"Health Commission of Jilin Province","doi-asserted-by":"publisher","award":["2025WS\u2010KA007"],"award-info":[{"award-number":["2025WS\u2010KA007"]}],"id":[{"id":"10.13039\/501100020230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Nursing"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of a dyadic illness management\u2013based intervention (Dyadic Guidance and Empowerment Program, D\u2010GEP) in alleviating demoralization among women with gynaecological malignancies and their family caregivers during the hospital\u2010to\u2010home transition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>An assessor\u2010blinded, two\u2010arm parallel randomized controlled trial with repeated outcome assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women\u2010caregiver dyads were recruited from a tertiary hospital in Changchun, China (June\u2013August 2025) and randomly allocated to the intervention or control group (1:1). The intervention group received D\u2010GEP, comprising two pre\u2010discharge face\u2010to\u2010face sessions, a 4\u2010week WeChat\u2010based video education programme comprising 20 videos, and a dyadic telephone follow\u2010up conducted 3\u2009weeks after discharge. The control group received standard discharge planning and a telephone follow\u2010up. Outcomes were assessed at baseline (T0), immediate post\u2010intervention (T1) and 3\u2009months post\u2010intervention (T2). Data were analysed according to the intention\u2010to\u2010treat principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of eighty\u2010four women\u2010caregiver dyads were recruited. Eighty women (95%) and 78 caregivers (93%) completed the full protocol. At 3\u2009months, D\u2010GEP significantly reduced demoralization among both women and family caregivers compared with standard care, with large intervention effect sizes observed. In addition, the symptom burden of women and family caregiver burden were also significantly reduced, whereas dyadic mutuality and family hardiness (women\u2010reported) improved. However, no significant effect was found on women's self\u2010perceived burden. The intervention demonstrated high adherence rates and minimal attrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The D\u2010GEP effectively reduces demoralization and improves key dyadic outcomes for women with gynaecological malignancies and their family caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for the Profession and\/or Patient Care<\/jats:title>\n                    <jats:p>Nurses can implement this theory\u2010driven dyadic programme to mitigate psychological distress and enhance mutual support, thereby facilitating improved continuity and quality of care during discharge and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>To our knowledge, this study provides randomized controlled evidence that a theory\u2010driven dyadic intervention may effectively reduce demoralization among women with gynaecological cancer and their family caregivers during the transition from hospital to home care. The scalable D\u2010GEP model, combining brief in\u2010person sessions, video education and telephone follow\u2010up, offers a practical framework for oncology nurses to integrate dyadic care into routine discharge planning. These findings have important implications for oncology practice in Asian healthcare systems and other settings where family engagement is central to cancer care delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Reporting Method<\/jats:title>\n                    <jats:p>This study was conducted and reported in accordance with the CONSORT 2025 guidelines for randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient or Public Contribution<\/jats:title>\n                    <jats:p>No Patient or Public Contribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry, No. ChiCTR2500104008. Registered on 10\/06\/2025, first recruitment on 20\/06\/2025.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.70739","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:48:15Z","timestamp":1787647695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a Dyadic Nursing Intervention on Women With Gynaecological Malignancies and Their Family Caregivers: A Randomized Controlled Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7087-5780","authenticated-orcid":false,"given":"Yanli","family":"Ji","sequence":"first","affiliation":[{"name":"Jilin University First Hospital Gynecology Department  ChangChun China"},{"name":"Jilin University College of Nursing  ChangChun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Changchun University of Traditional Chinese Medicine Information Technology Department  ChangChun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifei","family":"Che","sequence":"additional","affiliation":[{"name":"Jilin University First Hospital Gynecology Department  ChangChun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Qu","sequence":"additional","affiliation":[{"name":"Jilin University First Hospital Gynecology Department  ChangChun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wen","sequence":"additional","affiliation":[{"name":"Jilin University First Hospital Gynecology Department  ChangChun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Piao","sequence":"additional","affiliation":[{"name":"Jilin University First Hospital Gynecology Department  ChangChun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770130605"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4406"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/10499091211023482"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22355"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1238924"},{"issue":"8","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/jnci\/djad075","article-title":"Interventions to Improve Outcomes for Caregivers of Patients With Advanced Cancer: A Meta\u2010Analysis","volume":"115","author":"Chow R.","year":"2023","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517518"},{"issue":"1","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00005650-200301000-00013","article-title":"Measuring Chronic Patients' Feelings of Being a Burden to Their Caregivers \u2010 Development and Preliminary Validation of a Scale","volume":"41","author":"Cousineau N.","year":"2003","journal-title":"Medical Care"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2023.10.004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674211060746"},{"key":"e_1_2_12_16_1","volume-title":"Current Status and Influencing Factors of Demoralization Syndrome in Patients With Gynecological Cancer Undergoing Chemotherapy [D]","author":"Gong X. 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