{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:11:48Z","timestamp":1780603908887,"version":"3.54.1"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research Intellect Disabil"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Research into Rett syndrome has included various medical interventions. Non\u2010medical interventions are relatively under\u2010researched. Recent technological communication intervention advances have contributed to the evidence base in Rett syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The Embase, PsycINFO and MEDLINE were systematically searched for peer\u2010reviewed papers describing non\u2010medical interventions for Rett syndrome. All identified papers were evaluated for methodological quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen studies of adequate methodological quality were reviewed (across<jats:italic>N<\/jats:italic>\u00a0=\u00a060 participants). Interventions were primarily communication interventions including music, assistive technology, augmentative and alternative communication strategies, attentional training and cognitive rehabilitation training. All studies reported positive outcomes across communication, quality of life, brain stem activity, physical fitness and a reduction in stereotyped behaviour. However, methodological challenges to generalizability, standardization, lack of follow\u2010up and\/or small\u2010N samples were common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The review highlights the paucity of high\u2010quality research. Future research is needed to build on current research and improve validity and generalizability of interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jar.12694","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T09:58:45Z","timestamp":1576231125000},"page":"808-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Non\u2010medical interventions for individuals with Rett syndrome: A systematic review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-3648","authenticated-orcid":false,"given":"Annika Nina","family":"Amoako","sequence":"first","affiliation":[{"name":"Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dougal Julian","family":"Hare","sequence":"additional","affiliation":[{"name":"Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7441.702"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8578.2006.00426.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08856257.2011.640489"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04877"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1525740112453165"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08098130709478172"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10400435.2015.1092182"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2003.tb00404.x"},{"key":"e_1_2_8_11_1","volume-title":"Systematic reviews: CRD\u2019s guidance for undertaking systematic reviews in health care","author":"Centre for Reviews and Dissemination and Akers, J.,","year":"2009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-015-2457-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-016-0498-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08098130409478114"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.03.020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13668259900033981"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00911"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-010-9207-z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-6128-0_12"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3148.2007.00369.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.07.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aip.2013.09.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10020"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250506"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/13668250120119626-1"},{"key":"e_1_2_8_27_1","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins J. P.","year":"2011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9604.00170"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0952-3383.2005.00383.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280150504225"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2006.10.001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2007.01024.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-013-9349-x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.037"},{"issue":"2","key":"e_1_2_8_35_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1469-8749.1998.tb15371.x","article-title":"Is the girl with Rett syndrome normal at birth?","volume":"40","author":"Leonard H.","year":"1998","journal-title":"Developmental Medicine and Child Neurology"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2003.00589.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2011.629374"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-017-9196-7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.01.014"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3037-7"},{"key":"e_1_2_8_41_1","volume-title":"Development of a Quality Appraisal Tool for Case Series Studies Using a Modified Delphi Technique","author":"Moga C.","year":"2012"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compedu.2017.06.005"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280150504199"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26610"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744629508090983"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.46.2.134"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.44.4.328"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2008.09.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2010.10.006"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-016-3006-z"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-015-9423-7"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2013.07.010"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2014.06.009"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.09.017"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001163-199304000-00009"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02178506"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/026565909100700306"},{"key":"e_1_2_8_60_1","first-page":"1","article-title":"Rett syndrome in Sweden. Neurodevelopment\u2010disability\u2010pathophysiology","volume":"369","author":"Witt Engerstrom I.","year":"1990","journal-title":"Acta Paediatrica Scandinavica. Supplement"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00336-9"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.04.001"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/08856250902793545"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3156.2009.00545.x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12141"}],"container-title":["Journal of Applied Research in Intellectual Disabilities"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjar.12694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jar.12694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jar.12694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jar.12694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T15:29:50Z","timestamp":1722180590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jar.12694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/jar.12694"],"URL":"https:\/\/doi.org\/10.1111\/jar.12694","archive":["Portico"],"relation":{},"ISSN":["1360-2322","1468-3148"],"issn-type":[{"value":"1360-2322","type":"print"},{"value":"1468-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"2018-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}