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Secondary goals were to study trend changes over time, and to analyse differences between patients admitted to medical and surgical departments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective observational study on data collected from the Minimum Basic Dataset (MBDS, Conjunto M\u00ednimo B\u00e1sico de Datos [CMBD]) of admissions of adults with Down syndrome to hospitals belonging to the Spanish National Health System from 1 January 1997 through 31 December 2014. We analysed epidemiological and clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed 28,716 admissions of 16,874 adult patients with Down syndrome. Men accounted for 58.2% of the sample, and the mean age on admission was 41\u2009\u00b1\u200913\u2009years, with an 11\u2010year increase in mean age during the study period. Admissions among persons with Down syndrome increased by 5% during the study period, with a noticeable rise in admissions of older adults and to medical departments. Almost one\u2010third of patients (31.8%) were admitted more than once. Age\u2010adjusted mortality was 15.7%. The most common comorbid conditions were chronic obstructive pulmonary disease (25%), hypothyroidism (18.6%), and epilepsy (14.3%). The departments with the highest numbers of admissions were internal medicine (26.3%), pulmonary medicine (6.9%), and general surgery (5.25%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospital admissions among Spanish adults with Down syndrome have increased in recent decades, especially in older patients. We identified substantial differences between patients admitted to medical and surgical departments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jar.13043","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T07:59:05Z","timestamp":1667030345000},"page":"143-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["What brings adults with Down syndrome to the hospital? 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