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We analysed epidemiological and clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed admissions of 11,594 adults with DS, mean age 47\u2009years. 1715 patients died (15%), being the highest mortality (35%) in individuals aged 50\u201359. A past medical history of cerebrovascular disease (aOR 2.95 [2.30\u20133.77]) or cancer (aOR 2.79 [2.07\u20133.75]), gross aspiration's admission (aOR 2.59 [2.20\u20133.04]), immobility (aOR 2.31 [1.46\u20133\u201062]), and readmission within 30\u2009days (aOR 2.43 [2.06\u20132.86]) were identified as predictors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adults with DS have a high in\u2010hospital mortality rate. The main predictors of death were cerebrovascular disease, cancer, early readmission, and conditions commonly associated with advanced dementia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jar.13187","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T14:02:00Z","timestamp":1704204120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of the circumstances associated with death and predictors of mortality in <scp>Spanish<\/scp> adults with <scp>Down syndrome<\/scp>, 1997\u20132014"],"prefix":"10.1111","volume":"37","author":[{"given":"Paloma","family":"Aparicio","sequence":"first","affiliation":[{"name":"Palliative Care Department Hospital Universitario Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Alonso\u2010Babarro","sequence":"additional","affiliation":[{"name":"Palliative Care Department Hospital Universitario La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Barba","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital Universitario Rey Juan Carlos  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Unit, Internal Medicine Department Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Unit, Internal Medicine Department Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-5597","authenticated-orcid":false,"given":"Diego Real","family":"de As\u00faa","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Unit, Internal Medicine Department Hospital Universitario de la Princesa  Madrid Spain"},{"name":"Down Syndrome Medical Interest Group\u2010USA (DSMIG\u2010USA)  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4321\/s0212-71992001000500005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRG1448"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/JAR.13043"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000471"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92673-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckl103"},{"volume-title":"Programa Espa\u00f1ol de Salud para Personas con S\u00edndrome de Down","year":"2021","author":"Borrel Mart\u00ednez J. 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