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Because PMIs require ongoing parent engagement, they must be developed in alignment with the needs of intended users. The present study examined caregiver opinions and preferences to inform the development of syndrome\u2010informed interventions for children with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Parents of children with DS (<jats:italic>n<\/jats:italic>\u2009=\u200934) participated in focus groups discussing PMI. Interviews were transcribed and a thematic analysis was applied to code the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three themes were identified: advantages of PMI, disadvantages of PMI and preferred features of PMI. To align with parent preferences, future PMIs for children with DS should require a brief time commitment, blend intervention activities into daily routines and include family members in activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings have implications for developing novel interventions to support early development in children with DS and other neurogenetic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jar.13307","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T23:54:17Z","timestamp":1728431657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Parent Perspectives on Parent\u2010Mediated Intervention for Young Children With Down Syndrome"],"prefix":"10.1111","volume":"37","author":[{"given":"Madison M.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Prevention Research Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2166-6166","authenticated-orcid":false,"given":"Kaylyn","family":"Van Deusen","sequence":"additional","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Prevention Research Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda E.","family":"Pinks","sequence":"additional","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Prevention Research Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Ceci","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Hepburn","sequence":"additional","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanial R.","family":"Riggs","sequence":"additional","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Prevention Research Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pulina","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Marcolin","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Onnivello","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Colaianni","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Psychology Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Daunhauer","sequence":"additional","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lanfranchi","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Fidler","sequence":"additional","affiliation":[{"name":"Department of Human Development &amp; Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Prevention Research Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"ATLAS.ti Scientific Software Development GmbH.2023.\u201cATLAS.ti Mac (Version 23.2.1). 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