{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:29:23Z","timestamp":1792621763458,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG078730"],"award-info":[{"award-number":["R03AG078730"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research Intellect Disabil"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To describe immediate and underlying causes of mortality (using ICD\u201010 codes) and survival rates of aging adults with Down syndrome (Ds).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This secondary analysis used the Healthy Aging and Intellectual Disabilities cohort. Adults with Ds (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009149, \u2265\u200950\u2009years at baseline) were matched 1:1 to adults with intellectual disabilities without Ds on age, sex and level of intellectual disability. Follow\u2010up was ~10\u2009years post\u2010baseline, or at death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most common immediate and underlying causes of death in adults with Ds were respiratory diseases\/infections, followed by cardiovascular disease and neuropsychiatric conditions. Unknown causes accounted for 29%\u201350% of deaths. Adults with Ds had higher mortality than matched comparators (HR\u2009=\u20095.05, 95% CI 3.10\u20137.47), increasing significantly with each year of age (HR\u2009=\u20091.08\/year, 95% CI 1.04\u20131.11).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Respiratory diseases, cardiovascular and neuropsychiatric conditions are important contributors to mortality in older adults with Ds, but large numbers of missing causes warrant cautious interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jar.70246","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:14:34Z","timestamp":1778685274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immediate and Underlying Causes of Death and Survival Rates in Aging Adults With Down Syndrome"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-163X","authenticated-orcid":false,"given":"T. I. M.","family":"Hilgenkamp","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Nevada  Las Vegas Nevada USA"},{"name":"Intellectual Disability Medicine Research, Department of General Practice Erasmus MC University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-8807","authenticated-orcid":false,"given":"A.","family":"Oppewal","sequence":"additional","affiliation":[{"name":"Intellectual Disability Medicine Research, Department of General Practice Erasmus MC University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of Nevada  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-0720","authenticated-orcid":false,"given":"D. A. M.","family":"Maes\u2010Festen","sequence":"additional","affiliation":[{"name":"Intellectual Disability Medicine Research, Department of General Practice Erasmus MC University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2010.02.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckl103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61604"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.17294\/2330-0698.1824"},{"key":"e_1_2_11_6_1","unstructured":"Coleman M.1981.Down Syndrome Preventive Medical Check List. 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