{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:21:24Z","timestamp":1787653284231,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304014\/2021\u20104"],"award-info":[{"award-number":["304014\/2021\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research Intellect Disabil"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Bruxism is frequent in individuals with Down syndrome (DS), and there is a need to identify patient profiles to develop treatment plans that meet their specific needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cluster analysis was applied on clinical, dentofacial, sleep, pharmacotherapy, and screen use cross\u2010sectional data from 101 children\/adolescents with DS (5\u201318\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cardiopathy and thyroid dysfunction were the most frequent health conditions. Centrally acting medications use increased with increasing age. Proxy\u2010reported and clinically based sleep bruxism (SB) was found in 5% of children and 46% of adolescents. Three clusters were generated: \u2018children without SB\u2019, \u2018children\/adolescents with lower frequency of SB\u2019, and \u2018adolescents with high frequency of SB\u2019. SB, age, reflux, antidepressant use, snoring, sleep time, and smartphone\/tablet use contributed most to cluster classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The group of adolescents with high frequency of SB was characterized by antidepressant use, snoring, reflux, shorter sleep, and longer screen usage time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jar.70287","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:28:38Z","timestamp":1784273318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep Bruxism, Pharmacotherapy, Sleep Aspects and Screen Use in Children and Adolescents With Down Syndrome: A Cluster Analysis"],"prefix":"10.1111","volume":"39","author":[{"given":"Sania Aparecida","family":"Miyagui","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"},{"name":"Casas Andr\u00e9 Luiz  Guarulhos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5224-1928","authenticated-orcid":false,"given":"Mariana","family":"dos Santos Fernandes","sequence":"additional","affiliation":[{"name":"Brazilian Dental Association  S\u00e3o Caetano do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9601-7058","authenticated-orcid":false,"given":"Lucas Fernandes","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0663-4062","authenticated-orcid":false,"given":"Aianne Souto","family":"Pizzolato","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-9546","authenticated-orcid":false,"given":"Beatriz Tom\u00e9 Martins","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-2272","authenticated-orcid":false,"given":"Paula Midori","family":"Castelo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de S\u00e3o Paulo  Diadema Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000293"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13563"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14395"},{"key":"e_1_2_14_5_1","first-page":"248","article-title":"Classification of Malocclusion","volume":"41","author":"Angle E. 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