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Here, we performed a genome\u2010wide association study (GWAS) with both a case\u2013control analysis using the <jats:styled-content style=\"fixed-case\">GEMMA<\/jats:styled-content> software accounting for population structure and a BayesB approach in the GenSel software applied to every 1\u00a0Mb window of <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s or haplotypes. The haplotypes were constructed from a genealogical tree using the population of 204 Siberian Huskies. The BayesB analyses identified six putative genomic candidate regions on <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>6, 9, 24, 27 and X. These regions explained a high percentage of genetic variance when compared with other genomic regions. The positional candidate genes <jats:italic>Q9<jats:styled-content style=\"fixed-case\">TSI<\/jats:styled-content>5_<jats:styled-content style=\"fixed-case\">CANFA<\/jats:styled-content><\/jats:italic> (matrix metalloproteinase 9 precursor) on <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>24, <jats:italic><jats:styled-content style=\"fixed-case\">ADAMTS<\/jats:styled-content>20<\/jats:italic> (<jats:styled-content style=\"fixed-case\">ADAM<\/jats:styled-content> metallopeptidase with thrombospondin type 1 motif, 20) on <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>27 and <jats:italic><jats:styled-content style=\"fixed-case\">MID<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MID<\/jats:styled-content>1 interacting protein 1) on <jats:styled-content style=\"fixed-case\">CFAX<\/jats:styled-content> are known to be functionally related to extracellular matrix remodelling, which might be important for gubernaculum elongation and thus interrupting normal testicular descent. Further mutation screening in these candidate regions on <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>6, 9, 24, 27 and X is needed. Next generation sequencing will help to uncover rare variants associated with cryptorchidism in this dog population.<\/jats:p>","DOI":"10.1111\/jbg.12064","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T11:04:14Z","timestamp":1385377454000},"page":"202-209","source":"Crossref","is-referenced-by-count":13,"title":["A genome\u2010wide association study for canine cryptorchidism in Siberian Huskies"],"prefix":"10.1111","volume":"131","author":[{"given":"X.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Animal Science Iowa State University Ames IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Onteru","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State University Ames IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Saatchi","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State 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