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The <jats:styled-content style=\"fixed-case\">INHBA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>4) and <jats:styled-content style=\"fixed-case\">TICAM<\/jats:styled-content>1 (<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>7) genes are strong candidates for trypanotolerance\u2010related traits. The coding sequence of both genes (3951\u00a0bp in total) were analysed in a panel including 79 Asian, African and European cattle (<jats:italic>Bos taurus<\/jats:italic> and <jats:italic>B. indicus<\/jats:italic>) to identify naturally occurring polymorphisms on both genes. In general, the genetic diversity was low. Nineteen of the 33 mutations identified were found just one time. Seventeen different haplotypes were defined for the <jats:styled-content style=\"fixed-case\">TICAM<\/jats:styled-content>1 gene, and 9 and 12 were defined for the exon 1 and the exon 2 of the <jats:styled-content style=\"fixed-case\">INHBA<\/jats:styled-content> gene, respectively. There was no clear separation between cattle groups. The most frequent haplotypes identified in West African taurine samples were also identified in other cattle groups including Asian zebu and European cattle. Phylogenetic trees and principal component analysis confirmed that divergence among the cattle groups analysed was poor, particularly for the <jats:styled-content style=\"fixed-case\">INHBA<\/jats:styled-content> sequences. The European cattle subset had the lowest values of haplotype diversity for both the exon1 (monomorphic) and the exon2 (0.077\u00a0\u00b1\u00a00.066) of the <jats:styled-content style=\"fixed-case\">INHBA<\/jats:styled-content> gene. Neutrality tests, in general, did not suggest that the analysed genes were under positive selection. The assessed scenario would be consistent with the identification of recent mutations in evolutionary terms.<\/jats:p>","DOI":"10.1111\/jbg.12181","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T06:14:08Z","timestamp":1442211248000},"page":"105-114","source":"Crossref","is-referenced-by-count":17,"title":["Lack of haplotype structuring for two candidate genes for trypanotolerance in cattle"],"prefix":"10.1111","volume":"133","author":[{"given":"I.","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"\u00c1rea de Gen\u00e9tica y Reproducci\u00f3n Animal SERIDA Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"P\u00e9rez\u2010Pardal","sequence":"additional","affiliation":[{"name":"CIBIO Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos Universidade do Porto Vair\u00e3o Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"INERA Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"\u00c1rea de Gen\u00e9tica y Reproducci\u00f3n Animal SERIDA Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Goyache","sequence":"additional","affiliation":[{"name":"\u00c1rea de Gen\u00e9tica y Reproducci\u00f3n Animal SERIDA Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10495390902786926"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3239-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2015.1053606"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026036"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509210103"},{"key":"e_1_2_6_7_1","first-page":"317","volume-title":"Documenting Domestication. 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