{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:42:38Z","timestamp":1790826158333,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010576","name":"Iowa Pork Producers Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Animal Breeding Genetics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objectives were to evaluate the interaction between host genetics and vaginal microbiota and their relationships with antibody (Ab) response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination and farrowing performance in commercial gilts. The farrowing performance traits were number born alive, number weaning (NW), total number born, number born dead, stillborn, mummies and preweaning mortality (PWM). The vaginal microbiota was collected on days 4 (D4) and 52 (D52) after vaccination for PRRSV. Blood samples were collected on D52 for Ab measurement. <jats:italic>Actinobacteria<\/jats:italic>, <jats:italic>Bacterioidetes<\/jats:italic>, <jats:italic>Firmicutes<\/jats:italic>, <jats:italic>Proteobacteria<\/jats:italic> and <jats:italic>Tenericutes<\/jats:italic> were the most abundant Phyla identified in the vaginal microbiota. Heritability ranged from ~0 to 0.60 (<jats:italic>Fusobacterium<\/jats:italic>) on D4 and from ~0 to 0.63 (<jats:italic>Terrisporobacter<\/jats:italic>) on D52, with 43 operational taxonomic units (OTUs) presenting moderate to high heritability. One major QTL on chromosome 12 was identified for 5 OTUs (<jats:italic>Clostridiales<\/jats:italic>, <jats:italic>Acinetobacter<\/jats:italic>, <jats:italic>Ruminococcaceae<\/jats:italic>, <jats:italic>Campylobacter<\/jats:italic> and <jats:italic>Anaerococcus<\/jats:italic>), among other 19 QTL. The microbiability for Ab response to PRRSV vaccination was low for both days (&lt;0.07). For farrowing performance, microbiability varied from &lt;0.001 to 0.15 (NW on D4). For NW and PWM, the microbiability was greater than the heritability estimates. <jats:italic>Actinobacillus<\/jats:italic>, <jats:italic>Streptococcus<\/jats:italic>, <jats:italic>Campylobacter<\/jats:italic>, <jats:italic>Anaerococcus<\/jats:italic>, <jats:italic>Mollicutes<\/jats:italic>, <jats:italic>Peptostreptococcus<\/jats:italic>, <jats:italic>Treponema<\/jats:italic> and <jats:italic>Fusobacterium<\/jats:italic> showed different abundance between low and high Ab responders. Finally, canonical discriminant analyses revealed that vaginal microbiota was able to classify gilts in high and low Ab responders to PRRSV vaccination with a misclassification rate of &lt;0.02. Although the microbiota explained limited variation in Ab response and farrowing performance traits, there is still potential to explore the use of vaginal microbiota to explain variation in traits such as NW and PWM. In addition, these results revealed that there is a partial control of host genetic over vaginal microbiota, suggesting a possibility for genetic selection on the vaginal microbiota.<\/jats:p>","DOI":"10.1111\/jbg.12456","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T08:23:30Z","timestamp":1574670210000},"page":"84-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Investigating the relationship between vaginal microbiota and host genetics and their impact on immune response and farrowing traits in commercial gilts"],"prefix":"10.1111","volume":"137","author":[{"given":"Leticia P.","family":"Sanglard","sequence":"first","affiliation":[{"name":"Department of Animal Science Iowa State University Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Schmitz\u2010Esser","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State University Ames Iowa"},{"name":"Interdepartmental Microbiology Graduate Program Iowa State University Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent A.","family":"Gray","sequence":"additional","affiliation":[{"name":"Smithfield Premium Genetic Rose Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C. L.","family":"Linhares","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic &amp; Production Animal Medicine Iowa State University Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Yeoman","sequence":"additional","affiliation":[{"name":"Department of Animal &amp; Range Sciences Montana State University Bozeman Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack C. M.","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State University Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan C.","family":"Niederwerder","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine\/Pathobiology Kansas State University Manhattan Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-208X","authenticated-orcid":false,"given":"Nick V. 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