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Therefore, this study aimed to estimate (co)variance components and identify genomic regions and pathways associated with ruminal acidosis in feedlot Nellore cattle fed high\u2010concentrate diets. It was utilized a dataset containing a total of 642 Nellore bulls that were genotyped from seven feedlot nutrition studies. The GGP Indicus 35k panel was used with the single step genome\u2010wide association study methodology in which the effects of the markers were obtained from the genomic values estimated by the GBLUP model. A bivariate model to estimate genetic correlations between the economically important traits and indicator traits for acidosis was used. The traits evaluated in this study that were nutritionally related to rumen acidosis included average daily gain (ADG), final body weight, time spent eating (TSE), time spent ruminating, rumenitis score (RUM), rumen absorptive surface area (ASA), rumen keratinized layer thickness (KER) and hot carcass weight (HCW). The identified candidate genes were mainly involved in the negative or non\u2010regulation of the apoptotic process, salivary secretion, and transmembrane transport. The genetic correlation between HCW and ASA was low positive (0.27\u2009\u00b1\u20090.23), and between ADG and ASA was high moderate (0.58\u2009\u00b1\u20090.59). A positive genetic correlation between RUM and all performance traits was observed, and TSE correlated negatively with HCW (\u22120.33\u2009\u00b1\u20090.21), ASA (\u22120.75\u2009\u00b1\u20090.48), and KER (\u22120.40\u2009\u00b1\u20090.27). The genetic association between economically important traits and indicator traits for acidosis suggested that Nellore cattle may be more sensitive to acidosis in feedlot systems.<\/jats:p>","DOI":"10.1111\/jbg.12860","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T12:11:08Z","timestamp":1708431068000},"page":"491-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of genomic regions and pathways associated with traits related to rumen acidosis in feedlot Nellore cattle"],"prefix":"10.1111","volume":"141","author":[{"given":"Daniela D.","family":"Estevam","sequence":"first","affiliation":[{"name":"Department of Animal Production School of Veterinary Medicine and Animal Science S\u00e3o Paulo State University (UNESP)  Botucatu S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-5014","authenticated-orcid":false,"given":"Johnny M.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Animal Science College of Technology and Agricultural Sciences S\u00e3o Paulo State University (UNESP)  Dracena S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-2011","authenticated-orcid":false,"given":"Fernando S. 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