{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:58:47Z","timestamp":1791464327450,"version":"4.3.4"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031940","name":"Canada Mink Breeders Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031941","name":"Nova Scotia Mink Breeders Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Animal Breeding Genetics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inbreeding increases the likelihood of deleterious recessive alleles becoming homozygous and consequently affecting economically important traits. Runs of homozygosity (ROH), the continuous homozygous segments of the genome and the higher than expected homozygosity (HOM) are genomic indicators of inbreeding, quantified as F\n                    <jats:sub>ROH<\/jats:sub>\n                    and F\n                    <jats:sub>HOM<\/jats:sub>\n                    , respectively. Previous ROH analyses in American mink (\n                    <jats:italic>Neogale vison<\/jats:italic>\n                    ) were restricted to scaffold\u2010level references and could not resolve long autozygous segments. In this study, we characterized ROH in 1413 mink genotyped with the Affymetrix Mink 70K panel (50,902 autosomal SNPs after quality control) on the chromosome\u2010level genome assembly and compared F\n                    <jats:sub>ROH<\/jats:sub>\n                    with F\n                    <jats:sub>HOM<\/jats:sub>\n                    and with pedigree\u2010based inbreeding (F\n                    <jats:sub>PED<\/jats:sub>\n                    ) derived from 24,633 pedigree records. ROH were detected in all individuals, with a mean of 149.61\u2009\u00b1\u200913.82 segments per individual. Segments longer than 8\u2009Mb, not detectable in earlier studies of this population, represented 12.86% of all ROH and accounted for 0.10 of the mean F\n                    <jats:sub>ROH<\/jats:sub>\n                    of 0.28. Mean F\n                    <jats:sub>HOM<\/jats:sub>\n                    and F\n                    <jats:sub>PED<\/jats:sub>\n                    were \u22120.03 and 0.02, respectively. ROH were unevenly distributed across chromosomes and chromosomes 1, 2, 3, 4, 6 and 11 harboured 78.59% of all segments. The Pearson correlation coefficient was highest (0.72) between F\n                    <jats:sub>ROH<\/jats:sub>\n                    and F\n                    <jats:sub>HOM<\/jats:sub>\n                    and moderate (0.34) between genomic inbreeding and F\n                    <jats:sub>PED<\/jats:sub>\n                    , increasing with ROH length to 0.35 for segments longer than 16\u2009Mb. Because the density of the marker panel limits the resolution of short segments, quantitative inference was restricted to ROH longer than 4\u2009Mb. Our results indicate that recent autozygosity in this closed population is concentrated in a small number of long genomic segments, providing an opportunity to inform mating decisions.\n                  <\/jats:p>","DOI":"10.1111\/jbg.70079","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:24:23Z","timestamp":1791462263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing Runs of Homozygosity and Inbreeding in American Mink Using\n                    <scp>SNP<\/scp>\n                    Data and Pedigree Information"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3327-7012","authenticated-orcid":false,"given":"Persia Carol","family":"Thapa","sequence":"first","affiliation":[{"name":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy Ngoc","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pourya","family":"Davoudi","sequence":"additional","affiliation":[{"name":"Agriculture and Horticulture Development Board (AHDB)  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4681-8214","authenticated-orcid":false,"given":"Ghader","family":"Manafiazar","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-5414","authenticated-orcid":false,"given":"Younes","family":"Miar","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"11","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101366","article-title":"Investigating Inbreeding in the Turkey (\n                     Meleagris gallopavo\n                  ) Genome","volume":"100","author":"Adams S. M.","year":"2021","journal-title":"Poultry Science"},{"issue":"3","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41437-020-00383-9","article-title":"An Evaluation of Inbreeding Measures Using a Whole\u2010Genome Sequenced Cattle Pedigree","volume":"126","author":"Alemu S. W.","year":"2021","journal-title":"Heredity"},{"issue":"3","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0299109","article-title":"Genome\u2010Wide Analysis of Population Structure, Effective Population Size and Inbreeding in Iranian and Exotic Horses","volume":"19","author":"Bazvand B.","year":"2024","journal-title":"PLoS One"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/d14040279"},{"issue":"13","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1111\/mec.13681","article-title":"Genomic Analysis Reveals Depression due to Both Individual and Maternal Inbreeding in a Free\u2010Living Mammal Population","volume":"25","author":"B\u00e9r\u00e9nos C.","year":"2016","journal-title":"Molecular Ecology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/302661"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201065565\u20101"},{"issue":"4","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrg.2017.109","article-title":"Runs of Homozygosity: Windows Into Population History and Trait Architecture","volume":"19","author":"Ceballos F. C.","year":"2018","journal-title":"Nature Reviews Genetics"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2664"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2014.05.034"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12859"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863\u2010024\u201001252\u20108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102052.2010.02155.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12711-019-0497-z","article-title":"Inbreeding Depression due to Recent and Ancient Inbreeding in Dutch Holstein\u2013Friesian Dairy Cattle","volume":"51","author":"Doekes H. P.","year":"2019","journal-title":"Genetics, Selection, Evolution"},{"issue":"6","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/688919","article-title":"Evolution of Inbreeding Avoidance and Inbreeding Preference Through Mate Choice Among Interacting Relatives","volume":"188","author":"Duthie A. B.","year":"2016","journal-title":"American Naturalist"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skae147"},{"key":"e_1_2_11_19_1","volume-title":"Introduction to Quantitative Genetics","author":"Falconer D. S.","year":"1996"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12012"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010018\u20104453\u2010z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863\u2010020\u20100824\u2010y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200069"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711\u2010017\u20100358\u20106"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12720"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11113234"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/09064702.2018.1501088"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-12-460","article-title":"Detecting Autozygosity Through Runs of Homozygosity: A Comparison of Three Autozygosity Detection Algorithms","volume":"12","author":"Howrigan D. P.","year":"2011","journal-title":"BMC Genomics"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1175408"},{"issue":"11","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","DOI":"10.3390\/genes10110938","article-title":"Genome\u2010Wide Runs of Homozygosity, Effective Population Size, and Detection of Positive Selection Signatures in Six Chinese Goat Breeds","volume":"10","author":"Islam R.","year":"2019","journal-title":"Genes"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201004341\u20105"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00223"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12020258"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/190.1.283"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080813"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.17.0419"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014\u20103820.2006.tb01128.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2021\u201021543"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711\u2010015\u20100169\u20106"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731117002671"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12259"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711\u2010017\u20100360\u2010z"},{"issue":"3","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ajhg.2008.08.007","article-title":"Runs of Homozygosity in European Populations","volume":"83","author":"McQuillan R.","year":"2008","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010020\u20106463\u2010x"},{"issue":"2","key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jhered\/esx069","article-title":"Genetic Costs of Domestication and Improvement","volume":"109","author":"Moyers B. T.","year":"2018","journal-title":"Journal of Heredity"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010022\u201008384\u20100"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12549"},{"issue":"1","key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s12864-023-09480-5","article-title":"Comparing Pedigree and Genomic Inbreeding Coefficients, and Inbreeding Depression of Reproductive Traits in Japanese Black Cattle","volume":"24","author":"Nishio M.","year":"2023","journal-title":"BMC Genomics"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13071232"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12526"},{"issue":"3","key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A Tool Set for Whole\u2010Genome Association and Population\u2010Based Linkage Analyses","volume":"81","author":"Purcell S.","year":"2007","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102156\u201013\u201070"},{"key":"e_1_2_11_53_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711\u2010015\u20100153\u20101"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010023\u201009679\u20106"},{"issue":"2","key":"e_1_2_11_56_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/10495398.2020.1796696","article-title":"Genome\u2010Wide Assessment of Genetic Diversity, Linkage Disequilibrium and Haplotype Block Structure in Tharparkar Cattle Breed of India","volume":"33","author":"Saravanan K. A.","year":"2022","journal-title":"Animal Biotechnology"},{"key":"e_1_2_11_57_1","unstructured":"Sargolzaei M. H.Iwaisaki andJ. J.Colleau.2006. \u201cCFC: A Tool for Monitoring Genetic Diversity.\u201d In Proceedings of the 8th World Congress on Genetics Applied to Livestock Production Communication no: 27\u201328."},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12686\u2010018\u20101057\u20105"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/S175173111900332X"},{"key":"e_1_2_11_60_1","first-page":"1","article-title":"Estimation of Inbreeding and Identification of Regions Under Heavy Selection Based on Runs of Homozygosity in a Large White Pig Population","volume":"11","author":"Shi L.","year":"2020","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2361"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.05.003"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.12315"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.720081"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11050490"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010021\u201008280\u2010z"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863\u2010015\u20100227\u20107"},{"key":"e_1_2_11_68_1","unstructured":"Zhang Y. J.Young C.Wang X.Sun A.Wolc andJ.Dekkers.2014.Inbreeding by Pedigree and Genomic Markers in Selection Lines of PigsIn Proceedings of the 10th World Congress of Genetics Applied to Livestock Production: 17\u201022."},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/g3journal\/jkac118"},{"issue":"1","key":"e_1_2_11_70_1","doi-asserted-by":"crossref","first-page":"13352","DOI":"10.1038\/s41598-018-31802-x","article-title":"Genomic Analysis Reveals Genes Affecting Distinct Phenotypes Among Different Chinese and Western Pig Breeds","volume":"8","author":"Zhang Z.","year":"2018","journal-title":"Scientific Reports"},{"key":"e_1_2_11_71_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.livsci.2014.10.015","article-title":"Estimations of Genomic Linkage Disequilibrium and Effective Population Sizes in Three Sheep Populations","volume":"170","author":"Zhao F.","year":"2014","journal-title":"Livestock Science"}],"container-title":["Journal of Animal Breeding and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jbg.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jbg.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jbg.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:24:28Z","timestamp":1791462268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jbg.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":70,"alternative-id":["10.1111\/jbg.70079"],"URL":"https:\/\/doi.org\/10.1111\/jbg.70079","archive":["Portico"],"relation":{},"ISSN":["0931-2668","1439-0388"],"issn-type":[{"value":"0931-2668","type":"print"},{"value":"1439-0388","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jbg.70079"}}