{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:43:57Z","timestamp":1790527437966,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T00:00:00Z","timestamp":1354579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:bold>Clinical Outcome in Cardiac Resynchronization Therapy (CRT) Functional Responders<\/jats:bold>.\u2002<jats:bold><jats:italic>Introduction<\/jats:italic><\/jats:bold><jats:italic>:<\/jats:italic> We evaluated clinical outcome and incidence of (in)appropriate shocks in consecutive chronic heart failure (CHF) patients treated with CRT with a defibrillator (CRT\u2010D) according to functional response status. Furthermore, we investigated which factors predict such functional response.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods and Results<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>:<\/jats:italic> In a large teaching hospital, 179 consecutive CHF patients received CRT\u2010D in 2005\u20132010. Patients were considered functional responders if left ventricular ejection fraction (LVEF) increased to \u226535% postimplantation. Analysis was performed on 142 patients, who had CRT\u2010D as primary prevention, complete data and a baseline LVEF &lt;35%. Endpoints consisted of all\u2010cause mortality, heart failure (HF) hospitalizations, appropriate shocks and inappropriate shocks. Median follow\u2010up was 3.0 years (interquartile range [IQR] 1.6\u20134.4) and median baseline LVEF was 20% (IQR 18\u201325%). The functional response\u2010group consisted of 42 patients. In this group no patients died, none were hospitalized for HF, none received appropriate shocks and 3 patients (7.1%) received \u22651 inappropriate shocks. In comparison, the functional nonresponse group consisted of 100 patients, of whom 22 (22%) died (P = 0.003), 17 (17%) were hospitalized for HF (P = 0.007), 17 (17%) had \u22651 appropriate shocks (P = 0.003) and 8 (8.1%) received \u22651 inappropriate shocks (P = 0.78). Multivariable analysis showed that left bundle branch block (LBBB), QRS duration \u2265150 milliseconds and no need for diuretics at baseline are independent predictors of functional response.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>:<\/jats:italic> Functional responders to CRT have a good prognosis and rarely need ICD therapy. LBBB, QRS duration \u2265150 milliseconds and lack of chronic diuretic use predict functional response. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 316\u2010322, March 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/jce.12037","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T08:41:07Z","timestamp":1350376867000},"page":"316-322","source":"Crossref","is-referenced-by-count":31,"title":["Functional Response to Cardiac Resynchronization Therapy is Associated with Improved Clinical Outcome and Absence of Appropriate Shocks"],"prefix":"10.1111","volume":"24","author":[{"given":"NICK VAN","family":"BOVEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KJELL","family":"BOGAARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAAP","family":"RUITER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEERT","family":"KIMMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DOMINIC","family":"THEUNS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABELLA","family":"KARDYS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VICTOR","family":"UMANS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146336.92331.D1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.22.2502"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.6.730"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm305"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.992552"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.07.006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191095"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq171"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01317.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.038"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.041"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00795-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.04.005"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.014324"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960898"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:30:02Z","timestamp":1698647402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/jce.12037"],"URL":"https:\/\/doi.org\/10.1111\/jce.12037","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,4]]}}}