{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:56Z","timestamp":1790116136424,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T00:00:00Z","timestamp":1354579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:bold>Cryoballoon versus Radiofrequency Ablation<\/jats:bold>.\u2002<jats:bold><jats:italic>Aim:<\/jats:italic><\/jats:bold> Catheter ablation of paroxysmal atrial fibrillation (PAF) is associated with an important risk of early and late recurrence, necessitating repeat ablation procedures. The aim of this prospective randomized patient\u2010blind study was to compare the efficacy and safety of cryoballoon (Cryo) versus radiofrequency (RF) ablation of PAF after failed initial RF ablation procedure.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Patients with a history of symptomatic PAF after a previous failed first RF ablation procedure were eligible for this study. Patients were randomized to Cryo or RF redo ablation. The primary endpoint of the study was recurrence of atrial tachyarrhythmia, including AF and left atrial flutter\/tachycardia, after a second ablation procedure at 1 year of follow\u2010up. All patients were implanted with a cardiac monitor (Reveal XT, Medtronic) to continuously track the cardiac rhythm. Patients with an AF burden (AF%) \u2264 0.5% were considered AF\u2010free (Responders), while those with an AF% &gt; 0.5% were classified as patients with AF recurrences (non\u2010Responders).<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Eighty patients with AF recurrences after a first RF pulmonary vein isolation (PVI) were randomized to Cryo (N = 40) or to RF (N = 40). Electrical potentials were recorded in 77 mapped PVs (1.9 \u00b1 0.8 per patient) in Cryo Group and 72 PVs (1.7 \u00b1 0.8 per patient) in RF Group (P = 0.62), all of which were targeted. In Cryo group, 68 (88%) of the 77 PVs were re\u2010isolated using only Cryo technique; the remaining 9 PVs were re\u2010isolated using RF. In RF group, all 72 PVs were successfully re\u2010isolated (P = 0.003 vs Cryo). By intention\u2010to\u2010treat, 23 (58%) RF patients were AF\u2010free vs 17 (43%) Cryo patients on no antiarrhythmic drugs at 1 year (P = 0.06). Three patients had temporary phrenic nerve paralysis in the Cryo group; the RF group had no complications. Of the 29 patients who had only Cryo PVI without any RF ablation, 11 (38%) were AF\u2010free vs 20 (59%) of the 34 patients who had RF only (P = 0.021).<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> When patients require a redo pulmonary vein isolation ablation procedure for recurrent PAF, RF appears to be the preferred energy source relative to Cryo. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 274\u2010279, March 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/jce.12038","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T19:54:35Z","timestamp":1350590075000},"page":"274-279","source":"Crossref","is-referenced-by-count":46,"title":["Cryoballoon Versus Radiofrequency for Pulmonary Vein Re\u2010Isolation After a Failed Initial Ablation Procedure in Patients with Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"24","author":[{"given":"EVGENY","family":"POKUSHALOV","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALEXANDER","family":"ROMANOV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SERGEY","family":"ARTYOMENKO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VERA","family":"BARANOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DENIS","family":"LOSIK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEVDA","family":"BAIRAMOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALEXANDER","family":"KARASKOV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUNEET","family":"MITTAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONATHAN S.","family":"STEINBERG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"CalkinsH KuckKH CappatoR BrugadaJ CammAJ ChenSA CrijnsHJ DamianoRJJr DaviesDW DiMarcoJ EdgertonJ EllenbogenK EzekowitzMD HainesDE HaissaguerreM HindricksG IesakaY JackmanW JalifeJ JaisP KalmanJ KeaneD KimYH KirchhofP KleinG KottkampH KumagaiK LindsayBD MansourM MarchlinskiFE McCarthyPM MontJL MoradyF NademaneeK NakagawaH NataleA NattelS PackerDL PapponeC PrystowskyE RavieleA ReddyV RuskinJN SheminRJ TsaoHM WilberD;Heart Rhythm Society Task Force on Catheter and Surgical Ablation of Atrial Fibrillation.: 2012 HRS\/EHRA\/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendationsfor Patient Selection Procedural Techniques Patient Management and Follow\u2010up Definitions Endpoints and Research Trial Design A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA) a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC) American Heart Association (AHA) the Asia Pacific Heart Rhythm Society (APHRS) and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation the American Heart Association the European Cardiac Arrhythmia Society the European Heart Rhythm Association the Society of Thoracic Surgeons the Asia Pacific Heart Rhythm Society and the Heart Rhythm Society Heart Rhythm2012;9:632\u2013696.e21."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01560.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01506.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.877852"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01923.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.964809"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.824789"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.046"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00788-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm227"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12038","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:30:07Z","timestamp":1698647407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,4]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/jce.12038"],"URL":"https:\/\/doi.org\/10.1111\/jce.12038","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,4]]}}}