{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:26:52Z","timestamp":1777530412786,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Endpoint of Persistent AF Ablation<\/jats:bold>. <jats:italic>Background:<\/jats:italic> The endpoint of persistent atrial fibrillation (AF) ablation is still a matter of debate. The purpose of this study was to evaluate if sinus rhythm (SR) as endpoint of persistent AF ablation has a better long\u2010term outcome compared to atrial tachycardia (AT) or AF at the end of the procedure.<\/jats:p><jats:p><jats:italic>Methods and Results:<\/jats:italic> Between 2008 and 2011, 191 consecutive patients undergoing <jats:italic>de novo<\/jats:italic> catheter ablation for symptomatic persistent and long\u2010standing persistent AF using a sequential ablation approach (including pulmonary vein isolation, ablation of complex fractionated electrograms and linear lesions) were included in the study.<\/jats:p><jats:p>According to the result at the end of ablation procedure, patients were classified into 3 groups: patients with termination of AF into SR (Group 1, n = 62), patients with AT undergoing cardioversion (CV) (Group 2, n = 47), or patients with AF undergoing CV (Group 3, n = 82).<\/jats:p><jats:p>The primary endpoint was freedom from any atrial tachyarrhythmia off antiarrhythmic drugs at 12 months.<\/jats:p><jats:p>At 12 months, estimated proportions of patients free from any arrhythmia recurrence were 42% for Group 1, 13% for Group 2, and 25% for Group 3 (P = 0.002).<\/jats:p><jats:p>In a Cox regression analysis only termination into SR was associated with a lower risk of arrhythmia recurrence (HR: 0.62; P = 0.04).<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> If SR is achieved as endpoint of persistent and long\u2010standing persistent AF ablation using a sequential ablation approach it is associated with the highest long\u2010term single procedure success rate compared to AT or AF at the end of the procedure. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 388\u2010395, April 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/jce.12045","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T08:52:47Z","timestamp":1351155167000},"page":"388-395","source":"Crossref","is-referenced-by-count":47,"title":["Importance of Sinus Rhythm as Endpoint of Persistent Atrial Fibrillation 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