{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:32:03Z","timestamp":1768642323895,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Cardiac Resynchronization Therapy and QRS Axis<\/jats:bold>.\u2002<jats:bold><jats:italic>Background:<\/jats:italic><\/jats:bold> Mildly symptomatic heart failure (HF) patients derive substantial clinical benefit from cardiac resynchronization therapy with defibrillator (CRT\u2010D) as shown in MADIT\u2010CRT. The presence of QRS axis deviation may influence response to CRT\u2010D. The objective of this study was to determine whether QRS axis deviation will be associated with differential benefit from CRT\u2010D.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>:<\/jats:italic> Baseline electrocardiograms of 1,820 patients from MADIT\u2010CRT were evaluated for left axis deviation (LAD: quantitative QRS axis \u201030 to \u201090) or right axis deviation (RAD: QRS axis 90\u2013180) in left bundle branch block (LBBB), right bundle branch block (RBBB), and nonspecific interventricular conduction delay QRS morphologies. The primary endpoints were the first occurrence of a HF event or death and the separate occurrence of all\u2010cause mortality as in MADIT\u2010CRT.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold> Among LBBB patients, those with LAD had a higher risk of primary events at 2 years than non\u2010LAD patients (20% vs 16%; P = 0.024). The same was observed among RBBB patients (20% vs 10%; P = 0.05) but not in IVCD patients (22% vs 23%; P = NS). RAD did not convey any increased risk of the primary combined endpoint in any QRS morphology subgroup. When analyzing the benefit of CRT\u2010D in the non\u2010LBBB subgroups, there was no significant difference in hazard ratios for CRT\u2010D versus ICD for either LAD or RAD. However, LBBB patients without LAD showed a trend toward greater benefit from CRT therapy than LBBB patients with LAD (HR for no LAD: 0.37, 95% CI: 0.26\u20130.53 and with LAD: 0.54, 95% CI: 0.36\u20130.79; P value for interaction = 0.18).<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold> LAD in non\u2010LBBB patients (RBBB or IVCD) is not associated with an increased benefit from CRT. In LBBB patients, those without LAD seem to benefit more from CRT\u2010D than those with LAD. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 442\u2010448, April 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/jce.12057","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T12:04:47Z","timestamp":1353067487000},"page":"442-448","source":"Crossref","is-referenced-by-count":26,"title":["QRS Axis and the Benefit of Cardiac Resynchronization Therapy in Patients with Mildly Symptomatic Heart Failure Enrolled in MADIT\u2010CRT"],"prefix":"10.1111","volume":"24","author":[{"given":"ANDREW","family":"BRENYO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MOHAN","family":"RAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALON","family":"BARSHESHET","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"CANNOM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AURELIO","family":"QUESADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SCOTT","family":"McNITT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID T.","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARTHUR J.","family":"MOSS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WOJCIECH","family":"ZAREBA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.027"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009540"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2685"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01626-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.121264"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.04.006"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000139311.32278.32"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960898"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191095"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.07.069"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr185"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp074"},{"key":"e_1_2_6_19_2","first-page":"1245","article-title":"Influence of the preimplantation QRS axis on responses to cardiac resynchronization therapy","volume":"61","author":"Garcia\u2010Seara J","year":"2008","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20708"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun081"},{"key":"e_1_2_6_22_2","first-page":"27","article-title":"Left axis deviation. An electrocardiographic mortality study","volume":"54","author":"Seavey PW","year":"1971","journal-title":"Trans Assoc Life Insur Med Dir Am"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90020-1"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T03:28:55Z","timestamp":1698636535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/jce.12057"],"URL":"https:\/\/doi.org\/10.1111\/jce.12057","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,17]]}}}