{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:39:55Z","timestamp":1768639195866,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Norepinephrine Transporter and Syncope<\/jats:title><jats:sec><jats:title>\u2003Introduction<\/jats:title><jats:p>Norepinephrine transporter inhibitors, such as sibutramine, have been shown to prevent vasovagal syncope induced by tilt testing in healthy volunteers. As a test of concept we assessed whether sibutramine prevents fainting in highly symptomatic VVS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This was an open label, dose\u2010ranging protocol of sibutramine 10, 15, and 20 mg daily for \u22654 weeks per dose, with progression dictated by response and tolerance. Responders were predefined as having &gt;50% reduction in spell frequency, compared to baseline spell frequency. The cohort included seven subjects (6 women; 32\u00a0\u00b1 7 years) who had a median of 593 faints over a median of 180 months. The patients had had 7\u00a0\u00b1 4 previous treatment attempts without a satisfactory response. The mean duration of exposure to 10 mg, 15 mg, and 20 mg doses were 45\u00a0\u00b1 33 days, 98\u00a0\u00b1 89 days, and 137\u00a0\u00b1 83 days. Six patients tolerated the maximum dose, and 1 patient dropped out due to adverse effects at 15\u00a0mg\/day. The median frequency of spells at baseline, 10, 15, and 20\u00a0mg\/day was 12, 4.4, 2.8, and 1 events\/28 days (P\u00a0= 0.0048). Five patients were responders and 2 were nonresponders. Among responders, the median frequency of spells at baseline, 10, 15, and 20\u00a0mg\/day was 14, 4.8, 0.8, and 0.4 events per 28 days (P\u00a0= 0.0089). No patients developed hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this open label series, sibutramine prevented vasovagal syncope in most highly symptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12111","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T10:04:59Z","timestamp":1360577099000},"page":"799-803","source":"Crossref","is-referenced-by-count":18,"title":["Norepinephrine Transport Inhibition for Treatment of Vasovagal Syncope"],"prefix":"10.1111","volume":"24","author":[{"given":"ROBERT S.","family":"SHELDON","sequence":"first","affiliation":[{"name":"Libin Cardiovascular Institute of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEBBIE","family":"RITCHIE","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute of Calgary  Calgary Alberta 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