{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:19:59Z","timestamp":1771510799259,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:00:00Z","timestamp":1364515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Reversible Dysfunction After Persistent AF Ablation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is a paucity of data on atrial injury following ablation of persistent atrial fibrillation (AF). This study aimed at assessing reversibility of atrial dysfunction after successful persistent AF ablation using cardiovascular magnetic resonance (CMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>CMR was performed during sinus rhythm (SR) in 20 consecutive patients with persistent AF at baseline (BL) within 24 hours after ablation and after 6\u2010month follow\u2010up (FU). Catheter ablation included atrial substrate modification using the stepwise approach following pulmonary vein isolation (PVI) in order to attempt termination of persistent AF. Active left (LA) and right atrial (RA) function were quantified by calculating the active emptying fraction (AEF) from transvalvular flow profiles using velocity encoded (VENC) CMR. LA appendage (LAA) function was quantified by measurements of peak a\u2010wave velocities from flow profiles perpendicular to the LAA orifice. Peri\u2010atrial edema was assessed using black\u2010blood T<jats:sub>2<\/jats:sub>\u2010weighted CMR. A significant improvement was found in LA\u2010AEF from 18 (12\u201326)% at BL to 25 (22\u201335)% at FU (P = 0.0001). Furthermore, RA\u2010AEF significantly increased from 31 (19\u201335)% at BL to 40 (35\u201351)% at FU (P &lt; 0.0001). A significant improvement was also found for LAA a\u2010wave velocities from 45 (31\u201365) cm\/s at BL to 62 (49\u201375) cm\/s at FU (P &lt; 0.01). The area of peri\u2010atrial edema on T<jats:sub>2<\/jats:sub>\u2010weighted CMR decreased from 1393 (1098\u20131797) mm<jats:sup>2<\/jats:sup> at BL to 24 (1\u201392) mm<jats:sup>2<\/jats:sup> at FU (P &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CMR demonstrates reversibility of LA, LAA, and RA dysfunction associated with resorption of peri\u2010atrial edema in patients with SR after persistent AF ablation.\u2002<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12125","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T19:52:33Z","timestamp":1361994753000},"page":"762-767","source":"Crossref","is-referenced-by-count":30,"title":["Cardiovascular Magnetic Resonance Demonstrates Reversible Atrial Dysfunction After Catheter Ablation of Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"24","author":[{"given":"KAI","family":"MUELLERLEILE","sequence":"first","affiliation":[{"name":"Department of Cardiology 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