{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:43:40Z","timestamp":1783529020912,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Ablation versus Drugs in Elderly Persistent AF<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We prospectively compared the efficacy, safety, and quality of life (QoL) impact of catheter ablation versus antiarrhythmic drugs (AAD) in elderly patients with persistent atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Four hundred and twelve consecutive patients, aged \u2265 70 years, underwent ablation (Group A, 153 patients) or AAD (Group B, 259 patients). Study endpoints: treatment failure (any AF\/AT lasting &gt;30 seconds) and treatment\u2010related adverse events (acute when \u22641 month of procedure and long term when &gt;1 month). At a follow\u2010up of 60\u00a0\u00b1\u00a017 months, 43% and 46% patients in Group B versus 58% and 76% in Group A were in sinus rhythm (SR), respectively, after one (P = 0.003) and 2 procedures (P\u00a0&lt;\u00a00.001). Fifteen acute adverse events occurred (6.7% in Group A vs 1% in Group B, P\u00a0&lt;\u00a00.001), mainly periprocedural cerebral thromboembolism (3.3% in Group A vs 0.7% in Group B, P = 0.058). Previous TIA\/stroke resulted the only independent predictor of periprocedural cerebrovascular accidents (OR 1.2, 95%IC 1.1\u20131.3). At follow\u2010up, 74 long\u2010term adverse events occurred (7.7% in Group A vs 23.9% in Group B, P\u00a0&lt;\u00a00.001) with Group B patients more often experiencing AAD\u2010related adverse events (12.7% vs 2.6%, P\u00a0&lt;\u00a00.001). Group A and absence of AF\/AT recurrences significantly improved QoL scores (P\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In elderly persistent AF patients, catheter ablation is more effective in maintaining SR and in improving QoL than AAD but is affected by a higher risk of embolic complications, particularly in patients with previous TIA\/stroke. Over time, Group A patients more likely discontinued AAD with a reduction of long\u2010term adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12126","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T19:52:32Z","timestamp":1361994752000},"page":"731-738","source":"Crossref","is-referenced-by-count":39,"title":["Long\u2010Term Efficacy and Safety of Two Different Rhythm Control Strategies in Elderly Patients with Symptomatic Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"24","author":[{"given":"ALESSANDRO","family":"BLANDINO","sequence":"first","affiliation":[{"name":"Cardiology Division Department of Internal Medicine San Giovanni Battista Hospital University of Turin  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELISABETTA","family":"TOSO","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Internal Medicine San Giovanni Battista Hospital University of Turin  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCO","family":"SCAGLIONE","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cardinal Guglielmo Massaia Hospital  Asti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MATTEO","family":"ANSELMINO","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Internal Medicine San Giovanni Battista Hospital University of Turin  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FEDERICO","family":"FERRARIS","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Internal Medicine San Giovanni Battista Hospital University of Turin  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVIDE","family":"SARDI","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Internal Medicine San Giovanni Battista Hospital University of Turin  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