{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:58:06Z","timestamp":1770440286504,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Cheyne\u2010Stokes Respiration and Arrhythmias<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate whether adequate treatment of Cheyne\u2010Stokes respiration (CSR) reduces the risk of arrhythmic events in patients with chronic heart failure (CHF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 403 registry patients with CHF (LVEF\u226445%, NYHA\u2010class\u22652) and implanted cardioverter\u2010defibrillator devices (ICD) was studied. They underwent overnight polygraphy, with 221 having mild or no CSR (apnea\u2010hypopnea index [AHI]&lt;15\/h), and 182 having moderate to severe CSR (AHI&gt;15\/h). Latter ones were offered therapy with adaptive servoventilation (ASV), which 96 patients accepted and 86 rejected. During follow\u2010up (21\u00b1 15 months) defibrillator therapies were recorded in addition to clinical and physiologic measures of heart failure severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Event\u2010free survival from (a) appropriate cardioverter\u2010defibrillator therapies and (b) appropriately monitored ventricular arrhythmias was shorter in the untreated CSR group compared to the treated CSR and the no CSR group. Stepwise Cox proportional hazard regression analysis showed untreated CSR (a: hazard ratio [HR] 1.99, 95% confidence interval [CI] 1.46\u20132.72, P &lt; 0.001; b: HR 2.19, 95%CI 1.42\u20133.37, P &lt; 0.001), but not treated CSR (a: HR 1.06, 95%CI 0.74\u20131.50; P = 0.77; b: HR 1.21, 95%CI 0.75\u20131.93, P = 0.43) was an independent risk factor. The treated CSR group showed improvements in cardiac function and respiratory stability compared to the untreated CSR group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates a decrease of appropriate defibrillator therapies by ASV treated CSR in patients with CHF and ICD. A reduced exposure to hyperventilation, hypoxia, and improvement in indices of CHF severity and neurohumoral disarrangements are potential causative mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12197","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T22:39:31Z","timestamp":1370471971000},"page":"1132-1140","source":"Crossref","is-referenced-by-count":43,"title":["Treatment of Cheyne\u2010Stokes Respiration Reduces Arrhythmic Events in Chronic Heart Failure"],"prefix":"10.1111","volume":"24","author":[{"given":"Thomas","family":"Bitter","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010J\u00fcrgen","family":"Gutleben","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"N\u00f6lker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Westerheide","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Bielefeld  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Prinz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zisis","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Horstkotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Diabetes Centre North Rhine\u2010Westphalia Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.08.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.12.068"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411304"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.08.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.902452"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.084"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2595"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00332-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.030"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq327"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0689"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.9908114"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.868786"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0216-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.12.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eul108"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq192"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp057"},{"key":"e_1_2_7_20_1","volume-title":"AASM Manual for Scoring Sleep","author":"Iber C","year":"2007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00045609"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.146522"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2003.08.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1967.16.1.20"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180199"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960633"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.048"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1056\/NEJM199711273372202","article-title":"A comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from near\u2010fatal ventricular arrhythmias","volume":"337","author":"The antiarrhythmic versus implantable defibrillators (AVID) investigators","year":"1997","journal-title":"N Engl J Med"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.138"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000049641.11675.EE"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.40"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.042440"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.4.392"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.683482"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.2.H536"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.7.1337"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp138"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.2.H536"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065227.04025.C2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.084"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-3-199802010-00006"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3450"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.967"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00298103"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.011"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp247"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:57:16Z","timestamp":1696222636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,11]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/jce.12197"],"URL":"https:\/\/doi.org\/10.1111\/jce.12197","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,11]]}}}