{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:07:48Z","timestamp":1791014868598,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>The Impact of Drug Discontinuation in Patients<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients treated with a temporary pacemaker (TPM) due to atrioventricular (AV) block are often monitored after discontinuation of AV node blocking drugs to evaluate the indication for permanent pacing. However, the impact of drug discontinuation is sparsely documented. We investigated to what extent drug discontinuation abolished the need for permanent pacemaker (PPM) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>All hospital records of patients who received a TPM at Aalborg Hospital, Denmark, between January 2000 and March 2011 (n = 575) were retrospectively reviewed. Patients with AV block who were treated with a TPM and concomitant cessation of drug therapy were included if there was no other underlying mechanism causing the AV block. AV blocking drugs included antiarrhythmic agents classes II\u2013IV and digoxin. Fifty\u2010five patients fulfilled our inclusion criteria.<\/jats:p><jats:p>Forty\u2010seven patients had an indication for a PPM at the initial hospital admission, despite drug discontinuation. Of the remaining 8 patients who were discharged without a PPM, 3 subsequently experienced events: 2 had recurrence of AV block requiring a PPM, and 1 experienced syncope. Thus, in total, 49 (89%) patients had a final indication for a permanent pacemaker (PPM).<\/jats:p><jats:p>Of patients receiving beta\u2010blocker monotherapy, 26 (96%) had an indication for a PPM. TPM implantation was complicated by infection or displacement in 11% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The vast majority of patients treated with a TPM due to AV block and who receive beta\u2010blockers alone or in combination with digoxin have a final indication for a PPM despite cessation of drug treatment. TPM are frequently associated with complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12211","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T06:54:57Z","timestamp":1371452097000},"page":"1255-1258","source":"Crossref","is-referenced-by-count":26,"title":["The Impact of Drug Discontinuation in Patients Treated with Temporary Pacemaker Due to Atrioventricular Block"],"prefix":"10.1111","volume":"24","author":[{"given":"MARIA BISGAARD","family":"KNUDSEN","sequence":"first","affiliation":[{"name":"Department of Cardiology and Center for Cardiovascular Research  Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNA MARGRETHE","family":"TH\u00d8GERSEN","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Center for Cardiovascular Research  Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00d8REN PIHLKJ\u00c6R","family":"HJORTSH\u00d8J","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Center for Cardiovascular Research  Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAM","family":"RIAHI","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Center for Cardiovascular Research  Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.032"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.057"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2009.39.9.367"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.5.902"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb01926.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1988.tb03095.x"},{"key":"e_1_2_6_8_1","first-page":"I163","article-title":"The comparative effects of diltiazem and verapamil on atrioventricular conduction and atrioventricular reentry tachycardia","volume":"52","author":"Rowland E","year":"1983","journal-title":"Circ Res"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1265"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90027-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90678-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eul185"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:43:14Z","timestamp":1696261394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,19]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/jce.12211"],"URL":"https:\/\/doi.org\/10.1111\/jce.12211","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,19]]}}}