{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:34:56Z","timestamp":1791506096589,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"St. Jude Medical, Sylmar, CA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ICD Programming for Shock Reduction<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Shock therapy delivery by implantable cardioverter\u2010defibrillators (ICD) can be painful and may have adverse consequences. Reducing shock burden for patients with ICDs would be beneficial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PROVIDE was a prospective, randomized study of primary prevention ICD patients. Patients in the experimental group received a combination of programmed parameters with higher detection rates, longer detection intervals, empiric antitachycardia pacing (ATP), and optimized supraventricular tachycardia (SVT) discriminators, while those in the control group were programmed with conventional parameters. Shock therapy and arrhythmic syncope were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1,670 patients enrolled (846 in the experimental group, 824 in the control group) and monitored over a follow\u2010up of 530 \u00b1 241 days, 202 patients received shock therapy for any cause (82 in the experimental group and 120 in the control group). The median time to first shock was significantly prolonged (13.1 vs 7.8\u00a0months, hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.47 to 0.82, P\u00a0= 0.0005) and the 2\u2010year shock rate significantly reduced (12.4% vs 19.4%, P\u00a0&lt; 0.001) in the experimental group compared to the control group. There was no increase in arrhythmic syncope (HR: 1.64, 95% CI: 0.69 to 3.90, P\u00a0= 0.26), while the overall mortality was reduced (HR: 0.7, 95% CI: 0.50 to 0.98, P\u00a0= 0.036) in the experimental group compared to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A combination of programmed parameters utilizing higher detection rate, longer detection intervals, empiric ATP, and optimized SVT discriminators reduced ICD therapies without increasing arrhythmic syncope and was associated with reduction in all\u2010cause mortality among ICD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.12273","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T11:52:41Z","timestamp":1377604361000},"page":"52-59","source":"Crossref","is-referenced-by-count":117,"title":["Programming Implantable Cardioverter\u2010Defibrillators in Patients with Primary Prevention Indication to Prolong Time to First Shock: Results from the PROVIDE Study"],"prefix":"10.1111","volume":"25","author":[{"given":"MOHAMMAD","family":"SAEED","sequence":"first","affiliation":[{"name":"Texas Heart Institute, St. Luke's Episcopal Hospital  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IBRAHIM","family":"HANNA","sequence":"additional","affiliation":[{"name":"Cardiology, P.C  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIONYSSIOS","family":"ROBOTIS","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical Center  Worcester MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT","family":"STYPEREK","sequence":"additional","affiliation":[{"name":"Harbin Clinic Southeastern Cardiovascular Institute  Rome Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEO","family":"POLOSAJIAN","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Specialists  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AHMED","family":"KHAN","sequence":"additional","affiliation":[{"name":"Cardiology Consultants  Johnson City Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSEPH","family":"ALONSO","sequence":"additional","affiliation":[{"name":"Central Florida Heart Center  Ocala Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YELENA","family":"NABUTOVSKY","sequence":"additional","affiliation":[{"name":"St. Jude Medical  Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CURTIS","family":"NEASON","sequence":"additional","affiliation":[{"name":"St. Jude Medical  Sylmar California 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