{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:48:53Z","timestamp":1764251333365},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medtronic and Biotronik"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Subcutaneous Defibrillation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A purely subcutaneous implantable cardioverter defibrillator (ICD) requires higher energy but may be an effective alternative to transvenous ICDs to deliver lifesaving therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify combinations of anteroposterior subcutaneous shock pathways and waveforms with defibrillation efficacy comparable to transvenous ICDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Defibrillation testing was performed in 141 patients temporarily implanted with an active can emulator and subcutaneous coil electrodes. The patients were subdivided into 5 groups within 2 study phases. In all groups, a posterior electrode was positioned with its tip close to the spine. In the first study phase, 2 different can locations were evaluated: (1) an inframammary pocket (IM\u20101\u2013750), or (2) a conventional infraclavicular pocket (IC\u20101\u2013750). In both cases, a 70 J biphasic shock was used (peak voltage 750 V; 270 \u03bcF capacitance). In the second phase, configuration IC\u20101\u2013750 was enhanced by the addition of a second (parasternal) subcutaneous electrode (IC\u20102\u2013750). Furthermore, the effects of a different 70 J shock waveform (1,000 V, 160 \u03bcF) were evaluated for configurations IM\u20101\u2013750 and IC\u20102\u2013750 (becoming IM\u20101\u20131000 and IC\u20102\u20131000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of patients satisfying a defibrillation safety margin test of 2 consecutive successes at \u226450 J was 74%, 11%, and 44%, respectively, for the IM\u20101\u2013750, IC\u20101\u2013750, and IC\u20102\u2013750 configurations, and 93% and 86% for the IM\u20101\u20131000 and IC\u20102\u20131000 configurations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Defibrillation efficacy comparable to that of a transvenous system was achieved with an anteroposterior subcutaneous ICD configuration, with 160 \u03bcF capacitance, 1,000 V, and 70 J output. An infraclavicular pocket location becomes feasible if a parasternal subcutaneous coil is added.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12281","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T12:10:44Z","timestamp":1378469444000},"page":"29-35","source":"Crossref","is-referenced-by-count":10,"title":["A Multicenter Study of Shock Pathways for Subcutaneous Implantable Defibrillators"],"prefix":"10.1111","volume":"25","author":[{"given":"J\u00dcRGEN","family":"KUSCHYK","sequence":"first","affiliation":[{"name":"Department of Medicine\u2010Cardiology University Medical Centre  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GORAN","family":"MILASINOVIC","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia Institute for Cardiovascular Diseases  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VOLKER","family":"K\u00dcHLKAMP","sequence":"additional","affiliation":[{"name":"Herz\u2010Zentrum\u2010Bodensee  Konstanz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL R.","family":"ROBERTS","sequence":"additional","affiliation":[{"name":"Southampton University Hospital  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARKUS","family":"ZABEL","sequence":"additional","affiliation":[{"name":"Department of Cardiology Georg\u2010August\u2010Universit\u00e4t  Heart Centre G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCK","family":"MOLIN","sequence":"additional","affiliation":[{"name":"H\u00f4pital Laval  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN","family":"SHOROFSKY","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KURT D.","family":"STROMBERG","sequence":"additional","affiliation":[{"name":"Medtronic Inc Mounds View  Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL J.","family":"DEGROOT","sequence":"additional","affiliation":[{"name":"Medtronic Inc Mounds View  Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCIS D.","family":"MURGATROYD","sequence":"additional","affiliation":[{"name":"King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"207","article-title":"Experimental ventricular defibrillation with an automatic and completely implanted system","volume":"16","author":"Schuder JC","year":"1970","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02432.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)01032-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.01789.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2005.127902"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02949.x-i1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.09.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909545"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb00036.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.08.030"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12173"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1993.tb01657.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.2813"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb04662.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb00077.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01616.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.01.030"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00956.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12281","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T17:44:47Z","timestamp":1696182287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/jce.12281"],"URL":"https:\/\/doi.org\/10.1111\/jce.12281","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,9]]}}}