{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:16:15Z","timestamp":1793121375792,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007716","name":"Banyu Life Science Foundation International","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007716","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>V2S\/V3R Index Distinguishes LVOT from RVOT Origins<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although several ECG criteria have been proposed for differentiating between left and right origins of idiopathic ventricular arrhythmias (VA) originating from the outflow tract (OT\u2010VA), their accuracy and usefulness remain limited. This study was undertaken to develop a more accurate and useful ECG criterion for differentiating between left and right OT\u2010VA origins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We studied OT\u2010VAs with a left bundle branch block pattern and inferior axis QRS morphology in 207 patients who underwent successful catheter ablation in the right (RVOT; n = 154) or left ventricular outflow tract (LVOT; n = 53). The surface ECGs during the OT\u2010VAs and during sinus beats were analyzed with an electronic caliper. The V2S\/V3R index was defined as the S\u2010wave amplitude in lead V2 divided by the R\u2010wave amplitude in lead V3 during the OT\u2010VA. The V2S\/V3R index was significantly smaller for LVOT origins than RVOT origins (P &lt; 0.001). The area under the curve (AUC) for the V2S\/V3R index by a receiver operating characteristic analysis was 0.964, with a cut\u2010off value of \u22641.5 predicting an LVOT origin with an 89% sensitivity and 94% specificity. In the AUC and accuracy, the V2S\/V3R index was superior to any previously proposed ECG criteria in an analysis of all OT\u2010VAs. This advantage of the V2S\/V3R index over the V2 transition ratio and other indices also held true for a subanalysis of 77 OT\u2010VAs with a lead V3 precordial transition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The V2S\/V3R index outperformed other ECG criteria to differentiate left from right OT\u2010VA origins independent of the site of the precordial transition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12392","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T07:04:48Z","timestamp":1393311888000},"page":"747-753","source":"Crossref","is-referenced-by-count":167,"title":["A Novel Electrocardiographic Criterion for Differentiating a Left from Right Ventricular Outflow Tract Tachycardia Origin: The V2S\/V3R Index"],"prefix":"10.1111","volume":"25","author":[{"given":"NAOKI","family":"YOSHIDA","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKUMI","family":"YAMADA","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. THOMAS","family":"MCELDERRY","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YASUYA","family":"INDEN","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAYUKI","family":"SHIMANO","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOYOAKI","family":"MUROHARA","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VINEET","family":"KUMAR","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HARISH","family":"DOPPALAPUDI","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VANCE J.","family":"PLUMB","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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