{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:46:36Z","timestamp":1769129196813,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Renal Function and Outcomes After Defibrillator Implantation<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) reduce mortality in patients with heart failure (HF) and left ventricular dysfunction. However, their efficacy in patients with chronic kidney disease (CKD) is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the association between renal dysfunction and clinical outcomes in patients undergoing ICD and CRT defibrillator (CRTD) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from the Israeli ICD registry. Estimated glomerular filtration rate (eGFR) at implantation was assessed using the modification of diet in renal disease formula. Primary outcome was all\u2010cause mortality. Secondary outcomes included the composite endpoints of death or HF and death or ventricular arrhythmias (ventricular tachycardia\/ventricular fibrillation [VT\/VF]); any hospitalizations; first appropriate and inappropriate ICD therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period (July 2010\u2013November 2012), 2,811 patients were implanted with ICD or CRTD. One\u2010year follow\u2010up data were available for 730 ICD patients and 453 CRTD patients. Patients with eGFR &lt; 30 mL\/minute\/1.73 m<jats:sup>2<\/jats:sup> (n = 54, 4.6%) were older, had a higher prevalence of diabetes, hypertension, or ischemic heart disease. eGFR &lt;30 mL\/minute\/1.73 m<jats:sup>2<\/jats:sup> was associated with increased mortality risk in ICD (HR 5.4; 95% CI 1.5\u201319.2), but not in CRTD patients (HR 0.9; 95% CI 0.1\u20137.5). Renal dysfunction was associated with the composite endpoints of death or HF and death or VT\/VF in ICD, but not in CRTD patients. Mean eGFR during follow\u2010up decreased by 8.0 \u00b1 4.3 mL\/minute\/1.73 m<jats:sup>2<\/jats:sup> in ICD patients (P = 0.06) and by 1.8 \u00b1 1.3 mL\/minute\/1.73 m<jats:sup>2<\/jats:sup> in patients with CRTD (P = 0.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on this retrospective analysis, CKD is associated with adverse prognosis after ICD implantation, but not after CRTD implantation. GFR decreased in patients with ICD, but not in CRTD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12442","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T19:23:06Z","timestamp":1398367386000},"page":"990-997","source":"Crossref","is-referenced-by-count":13,"title":["Renal Dysfunction and Clinical Outcomes of Patients Undergoing ICD and CRTD Implantation: Data from the Israeli ICD Registry"],"prefix":"10.1111","volume":"25","author":[{"given":"ALON","family":"EISEN","sequence":"first","affiliation":[{"name":"Cardiology Department, Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAHMOUD","family":"SULEIMAN","sequence":"additional","affiliation":[{"name":"Cardiology Department, Rambam Medical Center  Bat Galim Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BORIS","family":"STRASBERG","sequence":"additional","affiliation":[{"name":"Cardiology Department, 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