{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:02:50Z","timestamp":1790204570505,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCRP Summer 2012 Clinical Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Renal Vein Stimulation Increases Blood Pressure<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurocardiogenic syncope (NCS) is a common and sometimes debilitating disorder, with no consistently effective treatment. NCS is due to a combination of bradycardia and vasodilation leading to syncope. Although pacemaker devices have been tried in treating the bradycardic aspect of NCS, no device\u2010based therapy exists to treat the coexistent vasodilation that occurs. The renal sympathetic innervation has been the target of denervation to treat hypertension. We hypothesized that stimulation of the renal sympathetic nerves can increase blood pressure and counteract vasodilation in NCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>High\u2010frequency stimulation (800\u2013900 pps, 10 V, 30\u2013200 seconds) was performed using a quadripolar catheter in the renal vein of 7 dogs and 1 baboon. A significant increase in blood pressure (BP; mean [SD] systolic BP 117 [\u00b128] vs. 128 [\u00b133], diastolic BP 75 [\u00b119] vs. 87 [\u00b129] mmHg) was noted during the stimulation, which returned to baseline after cessation of stimulation. The mean increase in systolic and diastolic BP was 13.0 (\u00b13.3) (P = 0.006) and 10.2 (\u00b14.6) (P = 0.08), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report the first ever study of feasibility and safety of high\u2010frequency electrical stimulation of the renal sympathetic innervation to increase BP in animal models. This has potential applications in the treatment of hypotensive states such as NCS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.12466","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T13:07:47Z","timestamp":1401973667000},"page":"1115-1118","source":"Crossref","is-referenced-by-count":16,"title":["Transvenous Stimulation of the Renal Sympathetic Nerves Increases Systemic Blood Pressure: A Potential New Treatment Option for Neurocardiogenic Syncope"],"prefix":"10.1111","volume":"25","author":[{"given":"MALINI","family":"MADHAVAN","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER V.","family":"DESIMONE","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases  Rochester Minnesota 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