{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T23:26:43Z","timestamp":1784503603792,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>VF from Papillary Muscle<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Animal studies showed that papillary muscles can be sources of ventricular fibrillation (VF) in both the left and right ventricle, but this occurrence in humans has been described only in patients with ischemic heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the role of papillary muscle premature ventricular contractions (PVCs) as triggers for VF and the safety and feasibility of catheter ablation in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six patients (2 male; age, 40 \u00b1 11 years; 5 with a normal structural heart and 1 with nonischemic cardiomyopathy) with history of VF resulting in repetitive implantable cardioverter defibrillator shocks, despite antiarrhythmic drug therapy, and a papillary muscle focus of PVCs triggering VF were included and underwent mapping and ablation of PVCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PVCs were observed to trigger VF and localized by mapping the earliest activation point that matched pace mapping of the same area. In 2 patients, PVCs originated from the left ventricle at the posteromedial papillary muscle; in 4 patients, PVCs originated from the right ventricle, at the posterolateral papillary muscle. Elimination of the triggering PVC was obtained in these areas after 19 \u00b1 12 minutes by radiofrequency application. During a follow\u2010up of 58 \u00b1 11 months using ambulatory monitoring and defibrillator memory interrogation, no patients had recurrence of symptomatic ventricular arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Papillary muscles from both ventricles represent an anatomic structure potentially involved in the onset of VF, also in normal structural heart. PVCs arising from this area can be successfully eliminated by radiofrequency ablation, resulting in freedom from recurrent VF at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12478","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T11:50:29Z","timestamp":1403265029000},"page":"1158-1164","source":"Crossref","is-referenced-by-count":108,"title":["Ventricular Fibrillation Triggered by PVCs from Papillary Muscles: Clinical Features and Ablation"],"prefix":"10.1111","volume":"25","author":[{"given":"FRANCESCO","family":"SANTORO","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Foggia  Foggia Italy"},{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIGI DI","family":"BIASE","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Foggia  Foggia 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