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Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Twenty\u2010eight dogs received 3 hours of continuous left\u2010sided electrical stimulation of RSN (LRS; Group\u20101, n = 9), sham RSN stimulation (Group\u20102, n = 9), or LSG ablation plus 3 hours of LRS (Group\u20103, n = 10) were included. AMI was induced by ligating the proximal left anterior descending coronary artery. LRS was performed using electrical stimulation on the adventitia of left renal artery at the voltage increasing the systolic blood pressure (BP) by 10%. BP, heart rate variability (HRV), serum norepinephrine (NE) level, and LSG function were measured at baseline and the end of each hour of LRS. C\u2010fos and nerve growth factor (NGF) protein expressed in the LSG were examined in Group\u20101 and Group\u20102. Compared with baseline, 3 hours of LRS induced a significant increase in BP, sympathetic indices of HRV, serum NE level, and LSG function. The incidence of VAs in Group\u20101 was significantly higher than other groups. The expression of c\u2010fos and NGF protein in the LSG was significantly higher in Group\u20101 than Group\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three hours of LRS induces both systemic and cardiac sympathetic hyperactivity and increases the incidence of ischemia\u2010induced VAs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12498","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T07:18:34Z","timestamp":1406531914000},"page":"1249-1256","source":"Crossref","is-referenced-by-count":48,"title":["Left Renal Nerves Stimulation Facilitates Ischemia\u2010Induced Ventricular Arrhythmia by Increasing Nerve Activity of Left Stellate Ganglion"],"prefix":"10.1111","volume":"25","author":[{"given":"BING","family":"HUANG","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan 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