{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:10:26Z","timestamp":1787317826812,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>T\u2010Wave Predicts CRT Response in LBBB Patients<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic heart failure patients with a left ventricular (LV) conduction delay, mostly due to left bundle branch block (LBBB), generally derive benefit from cardiac resynchronization therapy (CRT). However, 30\u201350% of patients do not show a clear response to CRT. We investigated whether T\u2010wave analysis of the ECG can improve patient selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>The study population comprised 244 CRT recipients with baseline 12\u2010lead electrocardiogram recordings. Echocardiographic response after 6\u2010month CRT was defined as a \u22655% increase in LV ejection fraction (LVEF). Vectorcardiograms (VCGs) were constructed from the measured 12\u2010lead ECGs using an adapted Kors algorithm on digitized ECGs. Logistic regression models indicated repolarization variables as good predictors of CRT response. The VCG\u2010derived T\u2010wave area predicted CRT response (odds ratio [OR] per 10 \u03bcVs increase 1.172 [P &lt; 0.001]) even better than QRS\u2010wave area (OR = 1.116 [P = 0.001]). T\u2010wave area had especially predictive value in the LBBB patient group (OR = 2.77 in LBBB vs. 1.09 in non\u2010LBBB). This predictive value persisted after adjustment of multiple covariates, such as gender, ischemia, age, hypertension, coronary artery bypass graft, and the usage of diuretics and \u03b2\u2010blockers. In LBBB patients, the increase in LVEF was 6.1 \u00b1 9.7% and 11.3 \u00b1 9.1% in patients with T\u2010wave area below and above the median value, respectively (P &lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with LBBB morphology of the QRS complex, a larger baseline T\u2010wave area is an important independent predictor of LVEF increase following CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.12549","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T10:25:19Z","timestamp":1410949519000},"page":"176-183","source":"Crossref","is-referenced-by-count":39,"title":["T\u2010Wave Area Predicts Response to Cardiac Resynchronization Therapy in Patients with Left Bundle Branch Block"],"prefix":"10.1111","volume":"26","author":[{"given":"ELIEN B.","family":"ENGELS","sequence":"first","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ESZTER M.","family":"V\u00c9GH","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAROLINE J.M.","family":"VAN DEURSEN","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEVIN","family":"VERNOOY","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cardiovascular Research Institute Maastricht Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAGMEET P.","family":"SINGH","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRITS W.","family":"PRINZEN","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.03.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.04.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960898"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0861"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.894774"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm207"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut049"},{"key":"e_1_2_8_11_1","first-page":"737","volume-title":"A Robust Open\u2010Source Algorithm to Detect Onset and Duration of QRS Complexes","author":"Zong W","year":"2003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2011.04.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059647"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2012.07.022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.065"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12057"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.1786"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.794834"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.061"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus039"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.520817"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.17.1724"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus272"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9200-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3282f2e260"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.046"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12101"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2010.03.010"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2010.03.009"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:19:37Z","timestamp":1696252777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/jce.12549"],"URL":"https:\/\/doi.org\/10.1111\/jce.12549","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]}}}