{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:00:28Z","timestamp":1767085228542},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,30]],"date-time":"2014-11-30T00:00:00Z","timestamp":1417305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>A Tricky Case of Pediatric Overlap Syndrome<\/jats:title><jats:p>We describe the case of 2\u2010year\u2010old baby with compound heterozygosity for paternal and maternal alleles mutation of \u03b1\u2010subunit of the cardiac sodium channel (SCN5A), sinus node dysfunction, atrial flutter recurrences, and drug induced long\u2010QT syndrome. In this setting, we chose at first to perform linear ablation of cavotricuspid isthmus resulting in a bidirectional isthmus block. As a second step, we decided to implant a miniaturized loop recorder that, with a minimally invasive procedure, permits us to follow the development of the disease in order to define the future strategy. After 8\u00a0months follow\u2010up, automatic daily loop\u2010recorder transmissions disclose the complete absence of any arrhythmia along with asymptomatic ventricular pauses due to sinus node dysfunction. Echocardiography shows normal findings, in particular no left ventricular dysfunction.<\/jats:p>","DOI":"10.1111\/jce.12570","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T03:55:06Z","timestamp":1414382106000},"page":"346-349","source":"Crossref","is-referenced-by-count":5,"title":["Cavotricuspid Isthmus Ablation and Subcutaneous Monitoring Device Implantation in a 2\u2010Year\u2010Old Baby with 2 SCN5A Mutations, Sinus Node Dysfunction, Atrial Flutter Recurrences, and Drug Induced Long\u2010QT Syndrome: A Tricky Case of Pediatric Overlap Syndrome?"],"prefix":"10.1111","volume":"26","author":[{"given":"PAOLO DE","family":"FILIPPO","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Unit Cardiovascular Department Azienda Ospedaliera Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAOLA","family":"FERRARI","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Unit Cardiovascular Department Azienda Ospedaliera Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA","family":"IASCONE","sequence":"additional","affiliation":[{"name":"Genetica Molecolare, USSD Laboratorio di Genetica Medica Azienda Ospedaliera Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARCO","family":"RACHELI","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Azienda Ospedaliera Desenzano del Garda Gavardo  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELE","family":"SENNI","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Azienda Ospedaliera Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,30]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0818-6"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.29.4.469"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.6.1266"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318062"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2008.10.003"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut082"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.04.091"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120295"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.44"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13200"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/12618"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.12.1206"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000052672.97759.36"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144458.58660.BB"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.4.447"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00494-1"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12570","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:56:16Z","timestamp":1696258576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,30]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/jce.12570"],"URL":"https:\/\/doi.org\/10.1111\/jce.12570","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,30]]}}}