{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:02:37Z","timestamp":1792324957735,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ICD Programming in Ischemic and Nonischemic Cardiomyopathy<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The MADIT\u2010RIT trial demonstrated reduction of inappropriate and appropriate ICD therapies and mortality by high\u2010rate cut\u2010off and 60\u2010second\u2010delayed VT therapy ICD programming in patients with a primary prophylactic ICD indication. The aim of this analysis was to study effects of MADIT\u2010RIT ICD programming in patients with ischemic and nonischemic cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>First and total occurrences of both inappropriate and appropriate ICD therapies were analyzed by multivariate Cox models in 791 (53%) patients with ischemic and 707 (47%) patients with nonischemic cardiomyopathy. Patients with ischemic and nonischemic cardiomyopathy had similar incidence of first inappropriate (9% and 11%, P = 0.21) and first appropriate ICD therapy (11.6% and 14.1%, P = 0.15). Patients with ischemic cardiomyopathy had higher mortality rate (6.1% vs. 3.3%, P = 0.01). MADIT\u2010RIT high\u2010rate cut\u2010off (arm B) and delayed VT therapy ICD programming (arm C) compared with conventional (arm A) ICD programming were associated with a significant risk reduction of first inappropriate and appropriate ICD therapy in patients with ischemic and nonischemic cardiomyopathy (HR range 0.11\u20130.34, P &lt; 0.001 for all comparisons). Occurrence of total inappropriate and appropriate ICD therapies was significantly reduced by high\u2010rate cut\u2010off ICD programming and delayed VT therapy ICD programming in both ischemic and nonischemic cardiomyopathy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010rate cut\u2010off and delayed VT therapy ICD programming are associated with significant reduction in first and total inappropriate and appropriate ICD therapy in patients with ischemic and nonischemic cardiomyopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12605","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T11:55:18Z","timestamp":1419681318000},"page":"424-433","source":"Crossref","is-referenced-by-count":30,"title":["The Effect of ICD Programming on Inappropriate and Appropriate ICD Therapies in Ischemic and Nonischemic Cardiomyopathy: The MADIT\u2010RIT Trial"],"prefix":"10.1111","volume":"26","author":[{"given":"KAMIL","family":"SEDL\u00c1\u010cEK","sequence":"first","affiliation":[{"name":"Cardiology Department Institute for Clinical and Experimental Medicine  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNE\u2010CHRISTINE","family":"RUWALD","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"},{"name":"Department of Cardiology Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VALENTINA","family":"KUTYIFA","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SCOTT","family":"MCNITT","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"POUL ERIK BLOCH","family":"THOMSEN","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Aalborg  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELMUT","family":"KLEIN","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTIN","family":"STOCKBURGER","sequence":"additional","affiliation":[{"name":"Charite\u2014Universit\u00e4tsmedizin Berlin Experimental and Clinical Research Centre  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAN","family":"WICHTERLE","sequence":"additional","affiliation":[{"name":"Cardiology Department Institute for Clinical and Experimental Medicine  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BELA","family":"MERKELY","sequence":"additional","affiliation":[{"name":"Heart Centre Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOAQUIN FERNANDEZ","family":"DE LA CONCHA","sequence":"additional","affiliation":[{"name":"Hospital Infanta Christina  Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOSHE","family":"SWISSA","sequence":"additional","affiliation":[{"name":"Kaplan Medical Centre Heart Institute  Bitaniz Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WOJCIECH","family":"ZAREBA","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARTHUR J.","family":"MOSS","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSEF","family":"KAUTZNER","sequence":"additional","affiliation":[{"name":"Cardiology Department Institute for Clinical and Experimental Medicine  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTIN H.","family":"RUWALD","sequence":"additional","affiliation":[{"name":"The Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York USA"},{"name":"Department of Cardiology Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MADIT\u2010RIT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00134.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.059"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.087"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.037"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4598"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211107"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq329"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0559-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2012.00531.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.04.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00297-3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033088"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000012350.99718.AD"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20970"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2010.19299"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145610.64014.E4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20949"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002472"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T09:58:41Z","timestamp":1695808721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,11]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/jce.12605"],"URL":"https:\/\/doi.org\/10.1111\/jce.12605","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,11]]}}}