{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:59:49Z","timestamp":1782154789774,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>QRS Fragmentation and QTc in Hypertrophic Cardiomyopathy<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>QRS fragmentation (fQRS) and prolonged QTc interval on surface ECG are prognostic in various cardiomyopathies other than hypertrophic cardiomyopathy (HCM). The association between fQRS and prolonged QTc duration with occurrence of ventricular tachyarrhythmias or sudden cardiac death (VTA\/SCD) in patients with HCM was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>One hundred and ninety\u2010five clinical HCM patients were studied. QTc duration was derived applying Bazett's formula; fQRS was defined as presence of various RSR\u2019 patterns, R or S notching and\/or &gt;1 additional R wave in any non\u2010aVR lead in patients without pacing or (in)complete bundle branch block. The endpoints comprised SCD, ECG documented sustained VTA (tachycardia or fibrillation) or appropriate implantable cardioverter defibrillator (ICD) therapies (antitachycardia pacing [ATP] or shock) for VTA in ICD recipients (n = 58 [30%]). QT prolonging drugs recipients were excluded. After a median follow\u2010up of 5.7 years (IQR 2.7\u20139.1), 26 (13%) patients experienced VTA or SCD. Patients with fQRS in \u22653 territories (inferior, lateral, septal, and\/or anterior) (p = 0.004) or QTc \u2265460 ms (p = 0.009) had worse cumulative survival free of VTA\/SCD than patients with fQRS in &lt;3 territories or QTc &lt;460 ms. fQRS in \u22653 territories (\u00df 4.5, p = 0.020, 95%CI 1.41\u201314.1) and QTc \u2265460 ms (\u00df 2.7, p = 0.037, 95%CI 1.12\u20136.33) were independently associated with VTA\/SCD. Likelihood ratio test indicated assessment of fQRS and QTc on top of conventional SCD risk factors provides incremental predictive value for VTA\/SCD (p = 0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both fQRS in \u22653 territories and QTc duration are associated with VTA\/SCD in HCM patients, independently of and incremental to conventional SCD risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12629","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T05:43:28Z","timestamp":1423028608000},"page":"547-555","source":"Crossref","is-referenced-by-count":58,"title":["QRS Fragmentation and QTc Duration Relate to Malignant Ventricular Tachyarrhythmias and Sudden Cardiac Death in Patients with Hypertrophic Cardiomyopathy"],"prefix":"10.1111","volume":"26","author":[{"given":"PHILIPPE","family":"DEBONNAIRE","sequence":"first","affiliation":[{"name":"Leiden University Medical Centre Department of Cardiology  Leiden 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