{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T19:26:44Z","timestamp":1708630004559},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Indiana Clinical Translational Sciences Institute","award":["NIH K08 HL95655, NIH R21 DE019686"],"award-info":[{"award-number":["NIH K08 HL95655, NIH R21 DE019686"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Zoledronic Acid Alters Atrial Electrophysiology<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Our objective was to determine effects of zoledronic acid (ZA) on atrial electrophysiological parameters and electrocardiographic measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p><jats:italic>Ex vivo perfusion study<\/jats:italic>: Isolated guinea pig hearts were perfused with modified Krebs\u2010Henseleit (K\u2010H) buffer with or without ZA 0.07 mg\/kg\/L (each n = 6). In ZA\u2010perfused hearts, atrial action potential at 90% repolarization (APD<jats:sub>90<\/jats:sub>) decreased more from baseline than in controls (\u221223.2% \u00b1 \u22125.1% vs. \u22122.1% \u00b1 \u22128.1%, P &lt; 0 .0001), as did APD<jats:sub>30<\/jats:sub> (\u221228.8% \u00b1 \u22123.8% vs. \u22122.1% \u00b1 \u22122.1%, P &lt; 0.0001). <jats:italic>In vivo dose\u2010response study<\/jats:italic>: Guinea pigs underwent intraperitoneal injections every 2 weeks in 1 of 4 groups (each n = 8): ZA 0.007 mg\/kg (low\u2010dose), ZA 0.07 mg\/kg (medium\u2010dose), ZA 0.7 mg\/kg (high\u2010dose), or placebo. Hearts were excised at 8 weeks and perfused with modified K\u2010H. Atrial effective refractory period (ERP) was lower with medium\u2010 and high\u2010dose ZA versus placebo (P = 0.004). Atrial APD<jats:sub>30<\/jats:sub> was lower with high\u2010dose ZA versus placebo, low and medium doses (P &lt; 0.001). <jats:italic>Canine ECG study<\/jats:italic>: Mature female beagles received intravenous ZA 0.067 mg\/kg or saline (placebo; each n = 6) every 2 weeks for 12 weeks. P wave dispersion was greater in the ZA group (7.7 \u00b1 3.7 vs. 3.4 \u00b1 2.6 ms, P = 0.04). There were no significant differences in P wave index, maximum or minimum P wave duration, or PR interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ZA shortens left atrial APD and ERP and increases P wave dispersion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12641","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T09:27:38Z","timestamp":1423906058000},"page":"671-677","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements"],"prefix":"10.1111","volume":"26","author":[{"given":"JAMES E.","family":"TISDALE","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Purdue University  Indianapolis Indiana USA"},{"name":"Division of Clinical Pharmacology Department of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATTHEW 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