{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:58:19Z","timestamp":1787623099706,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hacettepe University Research Projects Coordination Unit"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Cardiac Autoantibodies and AF Recurrence<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent evidence has suggested that autoantibodies may play an important role in the development of atrial fibrillation (AF). The predictive value of preprocedural autoantibodies against beta\u20101 adrenergic receptor (anti\u2010\u03b21\u2010R) and M2\u2010muscarinic acetylcholine receptor (anti\u2010M2\u2010R) for AF recurrence following cryoballoon\u2010based pulmonary vein isolation (PVI) is still unclear. We aimed to determine the predictive value of preprocedural anti\u2010\u03b21\u2010R and anti\u2010M2\u2010R levels for AF recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients (mean age 54.25 \u00b1 7.70 years; 40% female) with paroxysmal AF and preserved left ventricular function who underwent cryoballoon\u2010based PVI were included in the study. Preprocedural anti\u2010M2\u2010R and anti\u2010\u03b21\u2010R levels were measured with ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1\u2010year follow\u2010up after ablation, late AF recurrence was observed in 17 (21.25%) patients. In the Cox regression model, including number of antiarrhythmic drugs, early AF recurrence, anti\u2010\u03b21\u2010R levels &gt;159.88 ng\/mL, anti\u2010M2\u2010R levels &gt;277.65 ng\/mL, AF duration, and left atrial volume index, only anti\u2010\u03b21\u2010R levels &gt;159.88 ng\/mL (HR: 4.281, P = 0.039) and anti\u2010M2\u2010R levels &gt;277.65 ng\/mL (HR: 4.313, P = 0.030) were found to be independent predictors of late AF recurrence. Anti\u2010\u03b21\u2010R level &gt;159.88 ng\/mL was shown to predict late AF recurrence with a sensitivity of 70.59% and specificity of 90.48%. A cut\u2010off value of 277.65 ng\/mL for anti\u2010M2\u2010R level predicted AF recurrence with a sensitivity of 70.59% and specificity of 95.24%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preprocedural serum anti\u2010\u03b21\u2010R and anti\u2010M2\u2010R levels are independent predictors of late AF recurrence following cryoballoon\u2010based PVI in paroxysmal AF patients. Detection of preprocedural anti\u2010\u03b21\u2010R and anti\u2010M2\u2010R levels may serve as a novel method for determination of paroxysmal AF patients who may not benefit from cryoballoon\u2010based PVI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12665","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T07:29:24Z","timestamp":1426750164000},"page":"615-621","source":"Crossref","is-referenced-by-count":14,"title":["Cardiac Autoantibody Levels Predict Recurrence Following Cryoballoon\u2010Based Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation Patients"],"prefix":"10.1111","volume":"26","author":[{"given":"MUHAMMED ULVI","family":"YALCIN","sequence":"first","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine  Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KADRI MURAT","family":"GURSES","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kars Harakani 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