{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:46:27Z","timestamp":1791909987980,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Symptoms Before SADS<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>No studies in an unselected and nationwide setting have characterized the symptoms and medical history of patients with sudden arrhythmic death syndrome (SADS). The aim of this study was to identify and describe the symptoms and medical history of patients before the presentation of SADS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We have previously identified all of the autopsied sudden cardiac deaths (SCD; n = 314) in Danes aged 1\u201335 years between 2000 and 2006. After comprehensive pathological and toxicological investigation did not reveal a cause of SCD, 136 of the patients were identified as SADS. The National Patient Registry was utilized to obtain information on all in\u2010 and outpatient activity in Danish hospitals. All medical records from hospitals and general practitioners, including death certificates and autopsy reports were reviewed.<\/jats:p>\n                    <jats:p>Before death, 48 (35%) SADS patients had cardiac symptoms; among these, 30 (22%) had contacted the healthcare system. Antecedent symptoms (symptoms &gt;24 hours before death) were present in 34 (25%) patients. Prodromal symptoms (symptoms \u226424 hours before death) were present in 23 (17%) patients. Cardiac symptoms included chest pain (n = 16, 12%), dyspnea (n = 18, 13%), palpitations (n = 2, 1%), presyncope\/syncope (n = 23, 17%), and aborted SCD (n = 2, 1%). In addition, seizures (n = 25, 18%) were prevalent. In 61 (45%) SADS cases, no previous medical history were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this unselected, nationwide study of 136 young SADS patients, 35% had experienced cardiac symptoms before death, most commonly presyncope\/syncope, but only one out of five had contacted a healthcare provider with cardiac symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.12674","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T03:11:04Z","timestamp":1427253064000},"page":"761-767","source":"Crossref","is-referenced-by-count":44,"title":["Symptoms Before Sudden Arrhythmic Death Syndrome: A Nationwide Study Among the Young in Denmark"],"prefix":"10.1111","volume":"26","author":[{"given":"CHARLOTTE","family":"GLINGE","sequence":"first","affiliation":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC) University of Copenhagen  Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REZA","family":"JABBARI","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC) University of Copenhagen  Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BJARKE","family":"RISGAARD","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC) University of Copenhagen  Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS HADBERG","family":"LYNGE","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC) University of Copenhagen  Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS","family":"ENGSTR\u00d8M","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTINE M.","family":"ALBERT","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STIG","family":"HAUNS\u00d8","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC) University of Copenhagen  Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Medicine and Surgery Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BO GREGERS","family":"WINKEL","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC) University of Copenhagen  Denmark"},{"name":"Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Medicine and Surgery Copenhagen University Hospital  Rigshospitalet 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