{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:44:18Z","timestamp":1783133058123,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Second\u2010Generation Cryoballoon versus RF<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There are limited comparative data on catheter ablation of atrial fibrillation (CAAF) using the second\u2010generation cryoballoon (CB\u20102) versus point\u2010by\u2010point radiofrequency (RF). This study examines the acute\/long\u2010term CAAF outcomes using these 2 strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In this multicenter, retrospective, nonrandomized analysis, procedural and clinical outcomes of 1,196 patients (76% with paroxysmal AF) undergoing CAAF using CB\u20102 (n = 773) and open\u2010irrigated, non\u2010force sensing RF (n = 423) were evaluated. Pulmonary vein isolation was achieved in 98% with CB\u20102 and 99% with RF (P = 0.168). CB\u20102 was associated with shorter ablation time (40 \u00b1 14 min vs. 66 \u00b1 26 min; P &lt; 0.001) and procedure time (145 \u00b1 49 minutes vs. 188 \u00b1 42 minutes; P &lt; 0.001), but greater fluoroscopic utilization (29 \u00b1 13 minutes vs. 23 \u00b1 14 minutes; P &lt; 0.001). While transient (7.6% vs. 0%; P &lt; 0.001) and persistent (1.2% vs. 0%; P = 0.026) phrenic nerve palsy occurred exclusively with CB\u20102, other adverse event rates were similar between CB\u20102 (1.6%) and RF (2.6%); P = 0.207. However, freedom from AF\/atrial flutter\/tachycardia at 12 months following a single procedure without antiarrhythmic therapy was greater with CB\u20102 (76.6%) versus RF (60.4%); P &lt; 0.001. While this difference was evident in patients with paroxysmal AF (P &lt; 0.001), it did not reach significance in those with persistent AF (P = 0.089). Additionally, CB\u20102 was associated with reduced long\u2010term need for antiarrhythmic therapy (16.7% vs. 22.0%; P = 0.024) and repeat ablations (14.6% vs. 24.1%; P &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this multicenter, retrospective, nonrandomized study, CAAF using CB\u20102 coupled with RF as occasionally required was associated with greater freedom from atrial arrhythmias at 12 months following a single procedure without antiarrhythmic therapy when compared to open\u2010irrigated, non\u2010force sensing RF, alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12695","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T10:33:59Z","timestamp":1430130839000},"page":"832-839","source":"Crossref","is-referenced-by-count":100,"title":["Acute and Long\u2010Term Outcomes of Catheter Ablation of Atrial Fibrillation Using the Second\u2010Generation Cryoballoon versus Open\u2010Irrigated Radiofrequency: A Multicenter Experience"],"prefix":"10.1111","volume":"26","author":[{"given":"ARASH","family":"ARYANA","sequence":"first","affiliation":[{"name":"Regional Cardiology Associates and Dignity Health Heart &amp; Vascular Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHELDON M.","family":"SINGH","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCIN","family":"KOWALSKI","sequence":"additional","affiliation":[{"name":"Division of Cardiac Electrophysiology Staten Island University Hospital  Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEEP K.","family":"PUJARA","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery CHI Baylor St. Luke's Medical Center Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREW I.","family":"COHEN","sequence":"additional","affiliation":[{"name":"Aurora Denver Cardiology Associates  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEVE K.","family":"SINGH","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery CHI Baylor St. Luke's Medical Center Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RYAN G.","family":"ALEONG","sequence":"additional","affiliation":[{"name":"Division of Cardiac Electrophysiology University of Colorado  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAJESH S.","family":"BANKER","sequence":"additional","affiliation":[{"name":"Hoag Hospital, Newport Beach CA and University of California Irvine Medical Center  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHARLES E.","family":"FUENZALIDA","sequence":"additional","affiliation":[{"name":"Aurora Denver Cardiology Associates  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NELSON A.","family":"PRAGER","sequence":"additional","affiliation":[{"name":"Aurora Denver Cardiology Associates  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK R.","family":"BOWERS","sequence":"additional","affiliation":[{"name":"Regional Cardiology Associates and Dignity Health Heart &amp; 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