{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:34:16Z","timestamp":1769632456689,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Boston Scientific to the University of Rochester"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Sex Differences in VT\/VF or Death in MADIT\u2010CRT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Studies suggest that women with ischemic heart disease are less likely to experience appropriate ICD therapies for ventricular arrhythmias (VT\/VF). We evaluated the influence of sex on arrhythmic events or death in subjects enrolled in MADIT\u2010CRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Arrhythmic event rates, defined as VT\/VF treated with defibrillator therapy or all\u2010cause death, were determined among 1,790 subjects enrolled in MADIT\u2010CRT with documented 3\u2010year follow\u2010up. Predictors of VT\/VF\/death were identified using multivariate analysis. Ninety\u2010one (21%) women and 466 (35%) men experienced VT\/VF\/death over the follow\u2010up period. The overall probability of VT\/VF\/death was significantly lower in women versus men (HR 0.62; P &lt; 0.001). The probability of VT\/VF\/death was the lowest in women with ischemic heart disease (HR 0.51; P = 0.003). In ICD subjects, the 3\u2010year risk of VT\/VF was lower in ischemic women versus men (P = 0.021), and in nonischemic women versus men (P = 0.049). The probability of VT\/VF\/death was significantly lower in women (HR 0.52; P = 0.007) and men (HR 0.74; P = 0.018) with LBBB who received CRT\u2010D. Appropriate shock therapy strongly correlated with increased risk of death during postshock follow\u2010up in women (HR 5.18; P = 0.001) and men (HR 1.63; P = 0.033); interaction P value of 0.034.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this substudy of MADIT\u2010CRT, sex, etiology of heart disease and type of device implanted significantly influenced subsequent risk for VT\/VF or death. Women with ischemic heart disease and women with LBBB who received CRT\u2010D had the lowest incidence of VT\/VF or death when compared to men. Appropriate shock therapy was a strong predictor of death, particularly in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12701","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T10:35:32Z","timestamp":1430303732000},"page":"862-871","source":"Crossref","is-referenced-by-count":53,"title":["Sex Differences in Device Therapies for Ventricular Arrhythmias or Death in the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT\u2010CRT) Trial"],"prefix":"10.1111","volume":"26","author":[{"given":"CHRISTINE M.","family":"TOMPKINS","sequence":"first","affiliation":[{"name":"School of Medicine University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VALENTINA","family":"KUTYIFA","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester New York 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