{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:31:16Z","timestamp":1789201876025,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Dormant Conduction After Cryothermal PVI<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenosine triphosphate (ATP) testing reveals dormant pulmonary vein (PV) conduction after electrical PV isolation (PVI). This study aimed to evaluate the incidence of latent PV conduction after cryothermal PVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four consecutive paroxysmal atrial fibrillation patients undergoing cryothermal PVI were prospectively enrolled. PVI was performed with one 28\u2010mm second\u2010generation balloon using a 3\u2010minute freeze technique, and touch\u2010up lesions were created by focal cryothermal applications. ATP testing was performed following PVI with a 20\u2010mm circular mapping catheter placed in each PV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 217 PVs, 205 (94.5%) were isolated using a cryoballoon, and 12 required additional focal ablation. ATP testing was performed in 46 patients for 173 and 8 PVs, which were isolated by cryoballoons and focal ablation, respectively. No dormant PV conduction was provoked in any PVs, which were isolated by cryoballoons, whereas 4 (50.0%) out of 8 PVs requiring focal ablation had transient ATP\u2010provoked reconnections (0 vs. 50.0%, P &lt; 0.0001) with a median duration of 11.3 (10.7\u201317.1) seconds. The latent PV conduction site was identical to the residual conduction gap site after cryoballoon ablation in all. All latent conduction was successfully eliminated by 2 (2.0\u20139.5) additional focal applications. At a mean follow\u2010up of 7.7 \u00b1 1.6 months, 81.5% of the patients were arrhythmia free after a single procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No dormant PV conduction was provoked in PVs, which were isolated by 28\u2010mm second\u2010generation cryoballoons, but was provoked in 50% of PVs, which were isolated by focal cryoablation. These findings suggest that creating contiguous lesions is essential for eliminating dormant conduction in cryothermal ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12726","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T10:28:58Z","timestamp":1434364138000},"page":"1069-1074","source":"Crossref","is-referenced-by-count":11,"title":["Adenosine Triphosphate Test After Cryothermal Pulmonary Vein Isolation: Creating Contiguous Lesions Is Essential for Eliminating Dormant Conduction"],"prefix":"10.1111","volume":"26","author":[{"given":"SHINSUKE","family":"MIYAZAKI","sequence":"first","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROSHI","family":"TANIGUCHI","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROAKI","family":"NAKAMURA","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HITOSHI","family":"HACHIYA","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NOBORU","family":"ICHIHARA","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAKOTO","family":"ARAKI","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AKIO","family":"KUROI","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKAMITSU","family":"TAKAGI","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIN","family":"IWASAWA","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KENZO","family":"HIRAO","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHITO","family":"IESAKA","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.2463"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00621.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq079"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.192419"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.01.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.04031.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.ehj.2004.08.023","article-title":"Adenosine restores atrio\u2010venous conduction after apparently successful ostial isolation of the pulmonary veins","volume":"25","author":"Tritto M","year":"2004","journal-title":"Eur Heart J"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00753.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.10.008"},{"key":"e_1_2_7_13_1","first-page":"01","article-title":"Adenosine\u2010guided pulmonary vein isolation for the treatment of atrial fibrillation: Results of the prospective multicenter randomized trial","author":"Macle L","year":"2014","journal-title":"Heart Rhythm"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01501.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.01.047"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12571"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus048"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.893107"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.08.020"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02037.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058706.82623.A1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.046"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup339"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-012-0319-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000124478.98343.00"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.03.019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01224.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12114"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.12.026"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12726","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:33:02Z","timestamp":1696149182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,3]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/jce.12726"],"URL":"https:\/\/doi.org\/10.1111\/jce.12726","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,3]]}}}