{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:35:48Z","timestamp":1768347348297,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"CardioFocus"},{"name":"Hansen Medical and Boston Scientific"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Visually Guided PV Isolation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Visually guided laser balloon (VGLB) ablation is unique in that the operator delivers ablative energy under direct visual guidance. In this multicenter study, we sought to determine the feasibility, efficacy, and safety of performing pulmonary vein isolation (PVI) using this VGLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with symptomatic, drug\u2010refractory paroxysmal atrial fibrillation (AF) underwent PVI using the VGLB with the majority of operators conducting their first\u2010ever clinical VGLB cases. The primary effectiveness endpoint was defined as freedom from treatment failure that included: Occurrence of symptomatic AF episodes \u22651 minutes beyond the 90\u2010day blanking, the inability to isolate 1 superior and 2 total PVs, occurrence of left atrial flutter or atrial tachycardia, or left atrial ablation\/surgery during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 86 patients (mean age 56\u00a0\u00b1\u00a010 years, 67% male) were treated with the VGLB at 10 US centers. Mean fluoroscopy, ablation, and procedure times were 39.8\u00a0\u00b1\u00a024.3 minutes, 205.2 \u00b1 61.7 minutes, and 253.5\u00a0\u00b1\u00a071.3 minutes, respectively. Acute PVI was achieved in 314\/323 (97.2%) of targeted PVs. Of 84 patients completing follow\u2010up, the primary effectiveness endpoint was achieved in 50 (60%) patients. Freedom from symptomatic or asymptomatic AF was 61%. The primary adverse event rate was 16.3% (8.1% pericarditis, phrenic nerve injury 5.8%, and cardiac tamponade 3.5%). There were no cerebrovascular events, atrioesophageal fistulas, or significant PV stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This multicenter study of operators in the early stage of the learning curve demonstrates that PVI can be achieved with the VGLB with a reasonable safety profile and an efficacy similar to radiofrequency ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12727","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T10:28:47Z","timestamp":1434364127000},"page":"944-949","source":"Crossref","is-referenced-by-count":13,"title":["Pulmonary Vein Isolation Using the Visually Guided Laser Balloon: Results of the U.S. Feasibility Study"],"prefix":"10.1111","volume":"26","author":[{"given":"SRINIVAS R.","family":"DUKKIPATI","sequence":"first","affiliation":[{"name":"Helmsley Electrophysiology Center Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IAN","family":"WOOLLETT","sequence":"additional","affiliation":[{"name":"Sentara Cardiovascular Research Institute  Norfolk Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. THOMAS","family":"McELDERRY","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIE\u2010CHRISTINE","family":"B\u00d6HMER","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Center Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHEPHAL K.","family":"DOSHI","sequence":"additional","affiliation":[{"name":"Pacific Heart Institute  Santa Monica California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EDWARD P.","family":"GERSTENFELD","sequence":"additional","affiliation":[{"name":"University of California San Francisco School of Medicine  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RODNEY","family":"HORTON","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRE","family":"D'AVILA","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Center Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID E.","family":"HAINES","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital  Royal Oak Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIGUEL","family":"VALDERRABANO","sequence":"additional","affiliation":[{"name":"The Methodist Hospital  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. MICHAEL","family":"MANGRUM","sequence":"additional","affiliation":[{"name":"University of Virginia  Charlottesville Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEREMY N.","family":"RUSKIN","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA","family":"NATALE","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIVEK Y.","family":"REDDY","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Center Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946806"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.061"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.064"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup416"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.817205"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.933283"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.01.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000431"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12491"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu168"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02427.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-014-0624-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq326"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.690578"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.11.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus352"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu320"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu273"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.01.002"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12727","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.12727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:12:13Z","timestamp":1696219933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,10]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/jce.12727"],"URL":"https:\/\/doi.org\/10.1111\/jce.12727","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,10]]}}}