{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:07:41Z","timestamp":1788480461546,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Mortality After VT Substrate Ablation<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study sought to determine if the acute procedural outcome of ventricular tachycardia (VT) substrate ablation is associated with a mortality benefit in patients with implantable cardioverter\u2010defibrillators (ICD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>A total of 195 ICD recipients (65 \u00b1 11years) with ischemic or nonischemic dilated cardiomyopathy underwent substrate\u2010based ablation targeting elimination of local abnormal ventricular activities (LAVA). Acute procedural success, which was defined as elimination of all identified LAVA in addition to the lack of VT inducibility, was achieved in 95 (49%) patients. During a median follow\u2010up of 23 months, patients with acute procedure success had a significantly lower incidence of ICD shocks compared to those with ablation failure (8% vs. 30%, P &lt; 0.001). In multivariate analysis, acute procedural success was associated with a lower risk of VT recurrence (hazard ratio [HR] 0.30, 95% confidence interval [CI] 0.18\u20130.49, P &lt; 0.001) and all\u2010cause mortality (HR 0.32, 95% CI 0.17\u20130.60, P &lt; 0.001). While the impact of ablation success on mortality was not statistically significant in patients with LVEF &gt; 35% (HR 0.45, 95% CI 0.15\u20131.34, P = 0.15) and those with NYHA class I\/II (HR 0.63, 95% CI 0.29\u20131.40, P = 0.26), it was marked in patients with LVEF \u2264 35% (HR 0.30, 95% CI 0.14\u20130.62, P = 0.001) and NYHA class III\/IV (HR 0.17, 95% CI 0.05\u20130.57, P = 0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LAVA elimination in addition to VT noninducibility as a procedural outcome for substrate\u2010based ablation is associated with reduced mortality and better VT\u2010free survival during follow\u2010up. This prognostic benefit may be most pronounced in patients with severe heart failure as indicated by severely depressed LV function and NYHA class III\/IV symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.12825","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T14:31:29Z","timestamp":1441204289000},"page":"1230-1238","source":"Crossref","is-referenced-by-count":22,"title":["Impact of Substrate\u2010Based Ablation of Ventricular Tachycardia on Cardiac Mortality in Patients With Implantable Cardioverter\u2010Defibrillators"],"prefix":"10.1111","volume":"26","author":[{"given":"YUKI","family":"KOMATSU","sequence":"first","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, the Universit\u00e9 Victor Segalen Bordeaux II Institut LYRIC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPE","family":"MAURY","sequence":"additional","affiliation":[{"name":"Hospital Rangueil CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FR\u00c9D\u00c9RIC","family":"SACHER","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, the Universit\u00e9 Victor Segalen Bordeaux II Institut LYRIC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL","family":"KHAIRY","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Universit\u00e9 de Montr\u00e9al  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MATTHEW","family":"DALY","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, the Universit\u00e9 Victor Segalen Bordeaux II Institut LYRIC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAN S.","family":"LIM","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, the Universit\u00e9 Victor Segalen Bordeaux II Institut LYRIC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHAN","family":"ZELLERHOFF","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, the Universit\u00e9 Victor Segalen Bordeaux II Institut LYRIC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAURENCE","family":"JESEL","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, the Universit\u00e9 Victor Segalen Bordeaux II Institut LYRIC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNE","family":"ROLLIN","sequence":"additional","affiliation":[{"name":"Hospital Rangueil CHU Toulouse  Toulouse 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