{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:24:35Z","timestamp":1772627075541,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Impact of Continuous Positive Airway Pressure<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity\u2010hypoventilation syndrome (OHS) is defined as daytime hypercapnia and hypoxemia in obese patients with sleep\u2010disordered breathing. We evaluated the electrocardiographic P\u2010wave duration and dispersion (PD) and echocardiographic noninvasive indicators of atrial conduction heterogeneity in OHS patients and the impact of CPAP on atrial conduction and atrial fibrillation incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We enrolled 50 OHS patients and 50 sex\u2010 and age\u2010matched obese subjects as control. Study population underwent cardiologic evaluation and polysomnography before enrollment, at 1\u2010 and 6\u2010month follow\u2010ups after CPAP therapy. The OHS group showed a significant increase in inter\u2010atrial (35.2 \u00b1 8 milliseconds vs. 20.1 \u00b1 2.7 milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001), intra\u2010left (30.5 \u00b1 7.2 milliseconds vs. 16.5\u00a0\u00b1 2\u00a0milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001), and intra\u2010right atrial electromechanical delays (AEMD)(24.8 \u00b1 10 milliseconds vs. 15 \u00b1 2.6 milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001) as well as in Pmax (130 \u00b1 7.4 milliseconds vs. 97 \u00b1 7.2 milliseconds, <jats:italic>P<\/jats:italic> = 0.002) and PD (56.5 \u00b1 8.5 milliseconds vs. 31 \u00b1 7.2 milliseconds, <jats:italic>P<\/jats:italic> = 0.002) compared to the control group. Significant improvement was noted after 6 months of CPAP therapy in inter\u2010atrial (35.2 \u00b1 8 milliseconds vs. 24.5 \u00b1 6.3 milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001), intra\u2010left (30.5 \u00b1 7.2 milliseconds vs. 20.6 \u00b1 5 milliseconds, <jats:italic>P<\/jats:italic> = 0.003), and intra\u2010right AEMD (24.8 \u00b1 10 milliseconds vs. 17 \u00b1 7.5 milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001), as well as in Pmax (130 \u00b1 7.4 milliseconds vs. 95 \u00b1 10 milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001) and in PD (56.5 \u00b1 8.5 milliseconds vs. 32.5\u00a0\u00b1 6 milliseconds, <jats:italic>P<\/jats:italic> &lt; 0.0001) in the OHS group. External loop recorder monitoring detected paroxysmal AF in 19 OHS patients (38%) with significant reduction in paroxysmal AF episodes (12 \u00b1 6 vs. 47 \u00b1 12, <jats:italic>P<\/jats:italic> &lt; 0.0001) after 6\u2010month CPAP therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings showed a significant increase of electrocardiographic and echocardiographic indexes of atrial conduction heterogeneity in OHS patients. The CPAP therapy, having a positive impact on atrial conduction time, seems to reduce AF incidence in OHS patients<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12879","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T09:40:48Z","timestamp":1447148448000},"page":"327-334","source":"Crossref","is-referenced-by-count":19,"title":["Impact of Continuous Positive Airway Pressure Therapy on Atrial Electromechanical Delay in Obesity\u2010Hypoventilation Syndrome Patients"],"prefix":"10.1111","volume":"27","author":[{"given":"VINCENZO","family":"RUSSO","sequence":"first","affiliation":[{"name":"Chair of Cardiology, Second University of Naples AORN dei Colli\u2010Monaldi Hospital  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FEDERICA","family":"DI MEO","sequence":"additional","affiliation":[{"name":"Chair of Cardiology, Second University of Naples AORN dei Colli\u2010Monaldi Hospital  Naples 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