{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:46:30Z","timestamp":1780649190670,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Victorian Government's Operational Infrastructure"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>The Impact of Known Heart Disease on AF Ablation Outcomes<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catheter ablation for AF is an effective treatment for patients with AF and systolic LV dysfunction; however, the clinical outcome is variable. We evaluated the impact of cardiomyopathy etiology on long\u2010term outcomes post\u2010catheter ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing AF ablation across 3 centers (2 Australian, 1 UK) from 2002 to 2014, with LVEF&lt;45% were evaluated. Patients were stratified into those with known heart disease as a cause of cardiomyopathy (KHD), and those with idiopathic dilated cardiomyopathy (IDCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and one patients (IDCM = 77, KHD = 24) with AF and LVEF &lt;45% underwent AF ablation. The KHD group (ischemic HD in 67%) were older (61 \u00b1 7 vs. 55 \u00b1 11 years, P = 0.005), with a higher CHADS<jats:sub>2<\/jats:sub> score (2.0 \u00b1 0.8 vs. 1.6 \u00b1 0.7, P = 0.016), but otherwise well matched. After mean follow\u2010up of 36 \u00b1 23 months, AF control was greater in the IDCM group (82% vs. 50% in KHD, P &lt; 0.001). On multivariate analysis IDCM was associated with long\u2010term AF control (P = 0.033). The IDCM group had less functional impairment at follow\u2010up (NYHA class 1.5 \u00b1 0.7 vs. 2.0 \u00b1 0.8, P = 0.005) and improved LVEF (50 \u00b1 11% vs. 38 \u00b1 10%, P &lt; 0.001). Super responders (EF improvement &gt;15%) were overwhelmingly in the IDCM group (94% vs. 6%, P &lt; 0.001) with greater AF control (89% vs. 61%, P &lt; 0.001). All\u2010cause mortality was significantly higher in the KHD group (17% vs. 1.3%, P = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IDCM was associated with greater AF control, and improvement in symptoms and LVEF compared to patients with KHD post\u2010AF ablation. AF is an important reversible cause of HF in patients with an unexplained CM and catheter ablation an effective treatment option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12899","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T09:54:48Z","timestamp":1451296488000},"page":"281-289","source":"Crossref","is-referenced-by-count":29,"title":["The Impact of Known Heart Disease on Long\u2010Term Outcomes of Catheter Ablation in Patients with Atrial Fibrillation and Left Ventricular Systolic Dysfunction: A Multicenter International Study"],"prefix":"10.1111","volume":"27","author":[{"given":"SANDEEP","family":"PRABHU","sequence":"first","affiliation":[{"name":"Department of Cardiology Alfred Hospital  Victoria Australia"},{"name":"Baker IDI Heart and Diabetes Institute  Victoria Australia"},{"name":"Cardiology Department Royal Melbourne Hospital  Victoria Australia"},{"name":"Faculty of Medicine, Dentistry, and Health Sciences University of Melbourne  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Melbourne Hospital  Victoria Australia"},{"name":"Faculty of Medicine, Dentistry, and Health Sciences University of Melbourne  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREW J.","family":"TAYLOR","sequence":"additional","affiliation":[{"name":"Department of Cardiology Alfred Hospital  Victoria Australia"},{"name":"Baker IDI Heart and Diabetes Institute  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONATHAN M.","family":"KALMAN","sequence":"additional","affiliation":[{"name":"Cardiology Department Royal Melbourne Hospital  Victoria Australia"},{"name":"Faculty of Medicine, Dentistry, and Health Sciences University of Melbourne  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER M.","family":"KISTLER","sequence":"additional","affiliation":[{"name":"Department of Cardiology Alfred Hospital  Victoria Australia"},{"name":"Baker IDI Heart and Diabetes Institute  Victoria 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