{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:08:51Z","timestamp":1787015331948,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Cryoballoon Ablation for Persistent Atrial Fibrillation<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cryoballoon PVI has emerged as an alternative to radiofrequency PVI for the treatment of paroxysmal AF. The optimal strategy for patients with persistent AF is unclear as data are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed a prospective registry of consecutive patients with persistent AF who underwent Cryoballoon PVI at a single center between 2011 and 2014. Patients were assessed for atrial arrhythmia recurrence after a 3\u2010month blanking period at 6 months, 1 year, and 2 years postprocedure. Recurrence was based on typical symptoms, ECG, or event monitor evidence of AF. Kaplan\u2013Meier analysis was used to estimate arrhythmia\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Final analysis included 69 patients who underwent Cryoballoon PVI with a mean age 59.4 \u00b1 8.1 years, 85.5% male, 53.6% HTN patients, CHA2DS2\u2010VASC score 1.6 \u00b1 1.2, and LA size 4.5 \u00b1 0.6 cm. The single procedure atrial arrhythmia recurrence\u2010free rate at 1\u2010year postprocedure after a 3\u2010month blanking period was 59% and 50% at a mean follow\u2010up of 607 days. Of the recurrence\u2010free group, 17% were taking previously ineffective antiarrhythmic medications. In comparing patients with persistent AF duration &lt;1 year versus &gt;1 year, there was a trend toward greater AF recurrence\u2010free rates in the &lt;1 year group (66% vs. 55%, P = 0.09).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cryoballoon PVI appears to be an effective initial strategy in treating persistent AF, with an AF recurrence\u2010free rate of 59% at 1 year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.12924","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T09:24:13Z","timestamp":1452590653000},"page":"423-427","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy of Cryoballoon Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"27","author":[{"given":"EMILY N.","family":"GUHL","sequence":"first","affiliation":[{"name":"Center for Atrial Fibrillation, Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONALD","family":"SIDDOWAY","sequence":"additional","affiliation":[{"name":"Center for Atrial Fibrillation, Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EVAN","family":"ADELSTEIN","sequence":"additional","affiliation":[{"name":"Center for Atrial Fibrillation, Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREW","family":"VOIGT","sequence":"additional","affiliation":[{"name":"Center for Atrial Fibrillation, Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania 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