{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:43:53Z","timestamp":1762641833808},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universitat Polit\u00e8cnica de Val\u00e8ncia through its research initiative program","award":["PAID-2009-2013"],"award-info":[{"award-number":["PAID-2009-2013"]}]},{"name":"Generalitat Valenciana Grants","award":["ACIF\/2013\/021"],"award-info":[{"award-number":["ACIF\/2013\/021"]}]},{"name":"The Instituto de Salud Carlos III","award":["PI13-01882, PI13-00903"],"award-info":[{"award-number":["PI13-01882, PI13-00903"]}]},{"name":"Spanish Ministry Science and Innovation","award":["TEC2009-13939"],"award-info":[{"award-number":["TEC2009-13939"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>QRS Spatiotemporal Characteristics in Brugada Syndrome<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The diagnosis of Brugada syndrome based on the ECG is hampered by the dynamic nature of its ECG manifestations. Brugada syndrome patients are only 25% likely to present a type 1 ECG. The objective of this study is to provide an ECG diagnostic criterion for Brugada syndrome patients that can be applied consistently even in the absence of a type 1 ECG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We recorded 67\u2010lead body surface potential maps from 94 Brugada syndrome patients and 82 controls (including right bundle branch block patients and healthy individuals). The spatial propagation direction during the last r\u2019 wave and the slope at the end of the QRS complex were measured and compared between patients groups. Receiver\u2010operating characteristic curves were constructed for half of the database to identify optimal cutoff values; sensitivity and specificity for these cutoff values were measured in the other half of the database. A spontaneous type 1 ECG was present in only 30% of BrS patients. An orientation in the sagittal plane &lt; 101\u00ba during the last r\u2019 wave and a descending slope &lt; 9.65 mV\/s enables the diagnosis of the syndrome with a sensitivity of 69% and a specificity of 97% in non\u2010type 1 Brugada syndrome patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spatiotemporal characteristics of surface ECG recordings can enable a robust identification of BrS even without the presence of a type 1 ECG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12937","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:10:34Z","timestamp":1453471834000},"page":"563-570","source":"Crossref","is-referenced-by-count":5,"title":["Spatiotemporal Characteristics of QRS Complexes Enable the Diagnosis of Brugada Syndrome Regardless of the Appearance of a Type 1 ECG"],"prefix":"10.1111","volume":"27","author":[{"given":"MARIA S.","family":"GUILLEM","sequence":"first","affiliation":[{"name":"ITACA Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREU M.","family":"CLIMENT","sequence":"additional","affiliation":[{"name":"ITACA Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"},{"name":"Cardiology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOS\u00c9","family":"MILLET","sequence":"additional","affiliation":[{"name":"ITACA Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAOLA","family":"BERNE","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAFAEL","family":"RAMOS","sequence":"additional","affiliation":[{"name":"Unitat de Recerca en Atenci\u00f3 Primaria\u2010Girona Institut Catal\u00e0 de Salut  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSEP","family":"BRUGADA","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAMON","family":"BRUGADA","sequence":"additional","affiliation":[{"name":"Centre de Gen\u00e8tica Cardiovascular Universitat de Girona and Hospital Trueta  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000152479.54298.51"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2004.04.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01282.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.10.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2012.00499.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.000167"},{"key":"e_1_2_7_9_1","volume-title":"Machine Vision","author":"Jain R","year":"1995"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059647"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur395"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.039"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.07.012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.033"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.01.043"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1660"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00268.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.02.028"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.059"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01964-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.790543"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01677.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12937","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:29:16Z","timestamp":1696264156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/jce.12937"],"URL":"https:\/\/doi.org\/10.1111\/jce.12937","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}