{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T08:48:39Z","timestamp":1701766119237},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Vasovagal Syncope<\/jats:title><jats:p>Humans live primarily in the upright position; as a result, there is a constant struggle between gravity and needed supply of blood flow to the brain. In certain circumstances brain blood supply may become temporarily insufficient, resulting in syncope. Among the numerous causes of syncope in humans, vasovagal syncope (VVS) is by far the most common. However, despite intensive research, many aspects of the pathophysiology of VVS remain unknown; among these, one of the least well understood is the basis for why VVS is restricted, among vertebrates, to Homo sapiens. In this manuscript we review proposals that have been offered in an attempt to address the issue of the origin of VVS and, although highly speculative, we suggest a new hypothesis (the \u201cbrain theory\u201d) to try to address the question of why humans, to the exclusion of other species, remain susceptible to VVS. This theory suggests that VVS evolved to offer protection to the brain's functional integrity under certain conditions of severe threat. Although seemingly a disadvantageous evolutionary adaptation, the faint causes the body to take on a gravitationally neutral position, and thereby provides a better chance of restoring brain blood supply and preserving long\u2010term brain function.<\/jats:p>","DOI":"10.1111\/jce.12945","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T15:26:15Z","timestamp":1454513175000},"page":"623-629","source":"Crossref","is-referenced-by-count":6,"title":["Vasovagal Syncope: Hypothesis Focusing on Its Being a Clinical Feature Unique to Humans"],"prefix":"10.1111","volume":"27","author":[{"given":"JEAN\u2010JACQUES","family":"BLANC","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID G.","family":"BENDITT","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp298"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi647"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-008-0484-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91665-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12043"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2014.0072"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb03905.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000056105.87040.2B"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq071"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.257253"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00131.2004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90798-E"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960190212"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.7.777"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90235-S"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0549f.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.3.1157"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.298"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.10.1794"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01719-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.069"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/40\/2\/007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.1.017001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/25\/4\/004"},{"key":"e_1_2_6_26_1","first-page":"541","article-title":"Electroencephalographic study of syncopes. I: Electro\u2010clinical correlations in 150 cases of vago\u2010vagal syncope","volume":"95","author":"Gastaut H","year":"1956","journal-title":"Rev Neurol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.11.2347"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt332"},{"key":"e_1_2_6_29_1","first-page":"811","article-title":"Electroencephalographic findings during presyncope and syncope induced by tilt table testing","volume":"14","author":"Sheldon RS","year":"1998","journal-title":"Can J Cardiol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.88.3.217"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.08.016"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3301.094908"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1943.02290230022002"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.2011.0018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)70817-6"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-008-0479-7"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-003-0099-1"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2975"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01241-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00127-9"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-005-0244-0"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm563"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-005-0245-z"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798007144"},{"key":"e_1_2_6_45_1","first-page":"H305","article-title":"Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals","volume":"260","author":"Schadt JC","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31806864e2"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301085"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu367"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12945","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:29:05Z","timestamp":1696264145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/jce.12945"],"URL":"https:\/\/doi.org\/10.1111\/jce.12945","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}