{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:17Z","timestamp":1740137177416,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Clinical Outcome of Single\u2010 versus Dual\u2010Chamber ICDs<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the clinical outcomes of a single\u2010 versus dual\u2010chamber ICD for primary prevention of sudden cardiac death in a large, national ICD registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from the prospective Israeli ICD Registry. Baseline characteristics and clinical outcomes including mortality, admissions for heart failure (HF), and ICD therapy were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,125 subjects, 37% with a single\u2010chamber and 63% with a dual\u2010chamber ICD, constructed the baseline cohort. Approximately 80% had ischemic heart disease (IHD). Mean follow\u2010up was 22 months, mean ejection fraction was 30%, and mean QRS width was 103 milliseconds in both groups. During follow\u2010up, there were no significant differences in the rate of mortality, admissions for HF, appropriate or inappropriate therapy, or in time to any of the clinical outcomes. Using multivariate analysis, single\u2010chamber ICD was not associated with increased risk of death or admission for HF. In a subgroup of patients with IHD, single\u2010chamber ICD was associated with a higher rate of inappropriate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large retrospective population\u2010based cohort, dual\u2010chamber ICD showed no benefit in reducing the incidence of death or HF admissions, whereas in a subgroup of patients with IHD, single\u2010chamber ICD was associated with increased inappropriate therapy. Further prospective studies are necessary to assess the benefit of dual\u2010chamber ICD in reducing the rate of inappropriate therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12953","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T11:42:26Z","timestamp":1454931746000},"page":"718-723","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Outcomes of Single\u2010 versus Dual\u2010Chamber Implantable Cardioverter Defibrillators: Lessons from the Israeli ICD Registry"],"prefix":"10.1111","volume":"27","author":[{"given":"YUVAL","family":"KONSTANTINO","sequence":"first","affiliation":[{"name":"Cardiology Department Soroka Medical Center  Beer Sheva Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MOTI","family":"HAIM","sequence":"additional","affiliation":[{"name":"Cardiology Department Soroka Medical Center  Beer Sheva Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEREMY","family":"BOXER","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ILAN","family":"GOLDENBERG","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sheba Medical Center and the Israeli Association for Cardiovascular Trials (IACT) Neufeld Cardiac Research Institute  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDER","family":"FELDMAN","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ha Emek Medical Center  Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOAV","family":"MICHOWITZ","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel\u2010Aviv Sourasky Medical Center  Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL","family":"GLIKSON","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sheba Medical Center and the Israeli Association for Cardiovascular Trials (IACT) Neufeld Cardiac Research Institute  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAHMOUD","family":"SULEIMAN","sequence":"additional","affiliation":[{"name":"Cardiology Department Rambam Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the Israeli Working Group on Pacing and Electrophysiology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612263352601"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.05.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4982"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.039"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00789-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001442"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.061"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2005.00063.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211107"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu022"}],"container-title":["Journal 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