{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:03:35Z","timestamp":1761102215207},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Second\u2010Generation Cryoballoon Ablation<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lone atrial fibrillation (LAF) develops in younger individuals without cardiovascular or pulmonary disease. As pulmonary vein isolation has been recognized as an optimal treatment for drug\u2010resistant atrial fibrillation, cryoballoon ablation with second\u2010generation balloon (CB\u2010A) may be an ideal solution for LAF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate acute success, periprocedural complications and outcome over a 12\u2010month follow\u2010up period in a cohort of patients having undergone PV isolation (PVI) for LAF using CB\u2010A technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 consecutive patients (50 male, mean age 47 \u00b1 12 years) with a diagnosis of lone paroxysmal atrial fibrillation who underwent pulmonary vein isolation (PVI) by CB\u2010A from June 2012 were included. All patients underwent this procedure with the 28 mm CB\u2010A. A total of 299 PVs (100%) could be isolated with CB\u2010A alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The freedom from AF recurrence after a single procedure was 92% of patients during the entire 13\u2010month follow\u2010up. When considering a blanking period (BP) of 3 months, success rate was 93.3%. Transient phrenic nerve palsy (PNP) was the most frequent complication, occurring in 5.3% of individuals (4 patients); complete recovery was documented for all of these patients prior to hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CB\u2010A is extremely effective in achieving PVI and affords freedom from AF at 13\u2010month follow\u2010up in 93% of young patients affected by drug\u2010resistant LPAF following a 3\u2010month BP. The most frequent complication observed was PNP, which reverted prior to discharge in all patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12973","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T12:49:32Z","timestamp":1458650972000},"page":"677-682","source":"Crossref","is-referenced-by-count":8,"title":["Second\u2010Generation Cryoballoon Ablation in the Setting of Lone Paroxysmal Atrial Fibrillation: Single Procedural Outcome at 12 Months"],"prefix":"10.1111","volume":"27","author":[{"given":"VALENTINA","family":"DE REGIBUS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIACOMO","family":"MUGNAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DARRAGH","family":"MORAN","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Center  UZ Brussel\u2010VUB Brussels 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