{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:54:16Z","timestamp":1788803656164,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Embedded Electrode Ablation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intracardiac electrogram voltage remains an important metric for radiofrequency lesion application. Embedded micro\u2010electrodes within ablation catheters are now approved for use in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined electrogram characteristics of miniaturized electrode bipoles (iEGM<jats:sub>mini<\/jats:sub>) compared to distal ablation tip bipoles (iEGM<jats:sub>standard<\/jats:sub>) in the setting of typical atrial flutter in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center prospective trial involving 21 patients. A total of 54 non\u2010ablated and 56 ablated sites were analyzed offline by separate blinded observers for iEGM voltage after a clinically successful radiofrequency (RF) ablation for typical atrial flutter. Ablation sites were defined as sites that were localized anatomically within the RF lesion set and did not have atrial capture at 10 mA and 2 milliseconds. Non\u2010ablated sites were defined as sites adjacent to or remote from the ablation lesion set with capture at 10 mA and 2 milliseconds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>iEGM<jats:sub>mini<\/jats:sub> had greater voltages at non\u2010ablated sites and lower voltages at ablated sites than iEGM<jats:sub>standard<\/jats:sub> (non\u2010ablated sites iEGM<jats:sub>standard<\/jats:sub> 0.64 mV vs. iEGM<jats:sub>mini<\/jats:sub> 1.0 mV; ablated sites iEGM<jats:sub>standard<\/jats:sub> 0.15 mV, iEGM<jats:sub>mini<\/jats:sub> 0.08 mV, P &lt; 0.001). The difference for each patient between ablated and non\u2010ablated sites was greater for iEGM<jats:sub>mini<\/jats:sub> compared to iEGM<jats:sub>standard<\/jats:sub> (0.94 mV \u00b1 0.57 iEGM<jats:sub>mini<\/jats:sub> vs. 0.52 mV \u00b1 0.35 iEGM<jats:sub>standard<\/jats:sub>, P &lt; 0.001). Inter\u2010observer agreement was good among all non\u2010ablated sites and iEGM<jats:sub>mini<\/jats:sub> ablated sites, but was less robust for ablated sites using iEGM<jats:sub>standard<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Imbedded mini\u2010electrode iEGM bipoles had higher voltages in non\u2010ablated tissue, lower voltages in ablated tissue, and significantly greater intra\u2010patient differences between ablated and non\u2010ablated sites. These data suggest a potential role for miniaturized electrode bipole use in RF lesion monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12980","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T17:30:40Z","timestamp":1459618240000},"page":"820-824","source":"Crossref","is-referenced-by-count":13,"title":["Electrogram Characteristics of Ablated and Non\u2010Ablated Myocardium in Humans: A Comparison of Miniaturized Embedded Electrodes and Conventional Ablation Electrodes"],"prefix":"10.1111","volume":"27","author":[{"given":"MICHAEL S.","family":"LLOYD","sequence":"first","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL H.","family":"HOSKINS","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANAND D.","family":"SHAH","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONATHAN J.","family":"LANGBERG","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2004.09879.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00561.x"},{"key":"e_1_2_6_5_1","first-page":"1574","article-title":"Determinants of atrial lesion maturation during radio frequency ablation using localized tissue electrograms","volume":"2014","author":"Avitall B","year":"2014","journal-title":"J Innovat Cardiac Rhythm Manage"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12568"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780132310"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.annepidem.2010.02.011","article-title":"Assessment of disagreement: A new information\u2010based approach","volume":"20","author":"Costa\u2010Santos C","journal-title":"Ann Epidemiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.3.596"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.064"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.069"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.t01-1-00281.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00243.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02252.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030187.39852.A7"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12980","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:39:35Z","timestamp":1695746375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/jce.12980"],"URL":"https:\/\/doi.org\/10.1111\/jce.12980","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}