{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:01:48Z","timestamp":1770354108887,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Single 3 vs. Double 4 Strategy in CB ablation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Second\u2010generation cryoballoon (CB\u2010Adv) ablation is highly effective in achieving pulmonary vein isolation (PVI) with promising mid\u2010term clinical outcome. However, the ideal freezing strategy is still under debate. The aim of this study was to assess the efficacy of a single 3\u2010minute approach compared to the conventional 4\u2010minute plus bonus application using CB\u2010Adv.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>One hundred and sixty patients (67% male; mean age 58.0 \u00b1 13.3 years) underwent PVI using CB\u2010Adv for paroxysmal atrial fibrillation (PAF). Among 160 patients, 80 received a single 3\u2010minute approach (3\u2010mns group), while the remaining 80 conventional 4\u2010minute plus bonus\u2010freeze (4\u2010mns group). Mean procedure and fluoroscopy times were 90.6 \u00b1 15.8 and 18.3 \u00b1 6.9 in the 4\u2010mns group, 75.2 \u00b1 17.1 and 13.5 \u00b1 8.7 in the 3\u2010mns group (P &lt; 0.001, respectively). First\u2010freeze isolation rate was 91.6% in the 4\u2010 versus 90.6% in the 3\u2010mns group (P = 0.78). Persistent phrenic nerve palsy (PNP) occurred in 6\/80 (3.5%) in the 4\u2010mns group and 4\/80 in the 3\u2010mns group (P = 0.75). The overall freedom from ATas 2 years after the procedure was 78.1% (125\/160): 77.5% (62\/80 patients) in the 3\u2010mns and 78.8% (63\/80 patients) in the 4\u2010mns group (P = 0.82). In multivariate analysis, time to PVI and nadir temperature independently predicted ATa recurrences (P &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CB\u2010Adv ablation for PAF is highly effective, resulting in 78% 2\u2010year freedom from arrhythmic recurrences. A \u201csingle 3\u2010minute strategy\u201d showed equal efficacy as compared to the conventional 4\u2010minute plus bonus freeze approach at 2\u2010year follow\u2010up, providing shorter procedure and fluoroscopy time. Nadir temperature and time to PVI were predictors of arrhythmic recurrences. \u201cBonus\u2010freeze\u201d strategy might be unnecessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12986","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T09:07:19Z","timestamp":1460365639000},"page":"796-803","source":"Crossref","is-referenced-by-count":70,"title":["Single 3\u2010Minute versus Double 4\u2010Minute Freeze Strategy for Second\u2010Generation Cryoballoon Ablation: A Single\u2010Center Experience"],"prefix":"10.1111","volume":"27","author":[{"given":"GIUSEPPE","family":"CICONTE","sequence":"first","affiliation":[{"name":"Heart Rhythm Management Centre  UZ Brussel\u2010VUB Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUAN","family":"SIEIRA\u2010MORET","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre  UZ Brussel\u2010VUB Brussels 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